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- W2149142511 abstract "Many strategies have been proposed to induce tolerance to transplanted tissue in rodents; however, few if any have shown equal efficacy when tested in nonhuman primate transplant models. We hypothesized that a critical distinction between specific pathogen-free mice and nonhuman primates or human patients is their acquired immune history. Here, we show that a heterologous immune response — specifically, virally induced alloreactive memory — is a potent barrier to tolerance induction. A critical threshold of memory T cells is needed to promote rejection, and CD8+ “central” memory T cells are primarily responsible. Finally, treatment with deoxyspergualin, an inhibitor of NF-κB translocation, together with costimulation blockade, synergistically impairs memory T cell activation and promotes antigen-specific tolerance of memory. These data offer a potential explanation for the difficulty encountered when inducing tolerance in nonhuman primates and human patients and provide insight into the signaling pathways essential for memory T cell activation and function." @default.
- W2149142511 created "2016-06-24" @default.
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- W2149142511 date "2003-06-15" @default.
- W2149142511 modified "2023-10-10" @default.
- W2149142511 title "Heterologous immunity provides a potent barrier to transplantation tolerance" @default.
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- W2149142511 doi "https://doi.org/10.1172/jci17477" @default.
- W2149142511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/161424" @default.
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