FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149146517> ?p ?o ?g. }

• W2149146517 endingPage "221" @default.
• W2149146517 startingPage "213" @default.
• W2149146517 abstract "Functional and morphological alterations of the hepatic sinusoidal endothelial cell occur in several models of experimental liver injury and in clinical settings. The causes of these alterations are multiple. The aim of this study was to test the hypothesis that the early functional impairment and morphological alterations of the sinusoidal endothelial cell and hepatic sinusoid associated with liver injury are mediated by free radical species, such as superoxide anion and nitric oxide.Isolated rat livers were perfused by recirculation with hemoglobin-free, Krebs-Henseleit bicarbonate buffer and presented with a source of superoxide anion (xanthine oxidase+hypoxanthine) or nitric oxide (S-nitroso-N-acetyl penicillamine). Hyaluronan uptake (an index of sinusoidal endothelial cell scavenging function), thiobarbituric acid-reactive substances content of the tissue (a marker of lipid peroxidation), reduced and oxidized glutathione (a marker of the thiol system oxidation/reduction state), lactate dehydrogenase and alanine aminotransferase activities (markers of cytolysis), as well as scanning and transmission electron microscopic appearance of the sinusoid were evaluated.At the high concentrations used, both free radical generating systems suppressed hyaluronan uptake, increased malondialdehyde content of the tissue, enhanced the release of both liver enzymes, decreased the total glutathione content of the liver, and altered the ratio of reduced/oxidized glutathione. Both free radical species induced dose-dependent morphological alterations of the sinusoid, consisting of the appearance of large gaps replacing the sieve-plated fenestration.The free radical species-induced functional impairment and morphological alterations of the liver sinusoid, presented in this study, closely resemble the early in vivo changes associated with liver injury under a variety of conditions, such as preservation and reperfusion, or administration of hepatotoxicants such as D-galactosamine, Gram-negative bacterial lipopolysaccharides, acetaminophen, alcohol and others. Therefore, we suggest that early liver sinusoid injury, observed under these conditions, can be attributed to the action of free radicals, such as superoxide anion and nitric oxide." @default.
• W2149146517 created "2016-06-24" @default.
• W2149146517 creator A5012100988 @default.
• W2149146517 creator A5026544517 @default.
• W2149146517 creator A5035766443 @default.
• W2149146517 creator A5051219645 @default.
• W2149146517 creator A5052064903 @default.
• W2149146517 creator A5086404914 @default.
• W2149146517 date "1999-02-01" @default.
• W2149146517 modified "2023-10-18" @default.
• W2149146517 title "Effects of exogenous superoxide anion and nitric oxide on the scavenging function and electron microscopic appearance of the sinusoidal endothelium in the isolated, perfused rat liver" @default.
• W2149146517 cites W1141908684 @default.
• W2149146517 cites W1968640755 @default.
• W2149146517 cites W1971471687 @default.
• W2149146517 cites W1977538803 @default.
• W2149146517 cites W1980071084 @default.
• W2149146517 cites W1982650557 @default.
• W2149146517 cites W1991615383 @default.
• W2149146517 cites W1992166918 @default.
• W2149146517 cites W1995956658 @default.
• W2149146517 cites W2001239798 @default.
• W2149146517 cites W2001814742 @default.
• W2149146517 cites W2010146407 @default.
• W2149146517 cites W2011806139 @default.
• W2149146517 cites W2014717081 @default.
• W2149146517 cites W2020511880 @default.
• W2149146517 cites W2029428749 @default.
• W2149146517 cites W2031053608 @default.
• W2149146517 cites W2037984322 @default.
• W2149146517 cites W2040059149 @default.
• W2149146517 cites W2040308603 @default.
• W2149146517 cites W2045433670 @default.
• W2149146517 cites W2053054955 @default.
• W2149146517 cites W2055868611 @default.
• W2149146517 cites W2060088218 @default.
• W2149146517 cites W2067253087 @default.
• W2149146517 cites W2078611817 @default.
• W2149146517 cites W2083875409 @default.
• W2149146517 cites W2112236420 @default.
• W2149146517 cites W2119276522 @default.
• W2149146517 cites W2127668217 @default.
• W2149146517 cites W2147087352 @default.
• W2149146517 cites W2147868485 @default.
• W2149146517 cites W2154249136 @default.
• W2149146517 cites W2164109472 @default.
• W2149146517 cites W2200674871 @default.
• W2149146517 cites W2252723705 @default.
• W2149146517 cites W6594882 @default.
• W2149146517 doi "https://doi.org/10.1016/s0168-8278(99)80064-6" @default.
• W2149146517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10068098" @default.
• W2149146517 hasPublicationYear "1999" @default.
• W2149146517 type Work @default.
• W2149146517 sameAs 2149146517 @default.
• W2149146517 citedByCount "21" @default.
• W2149146517 countsByYear W21491465172012 @default.
• W2149146517 countsByYear W21491465172013 @default.
• W2149146517 countsByYear W21491465172014 @default.
• W2149146517 countsByYear W21491465172015 @default.
• W2149146517 countsByYear W21491465172021 @default.
• W2149146517 crossrefType "journal-article" @default.
• W2149146517 hasAuthorship W2149146517A5012100988 @default.
• W2149146517 hasAuthorship W2149146517A5026544517 @default.
• W2149146517 hasAuthorship W2149146517A5035766443 @default.
• W2149146517 hasAuthorship W2149146517A5051219645 @default.
• W2149146517 hasAuthorship W2149146517A5052064903 @default.
• W2149146517 hasAuthorship W2149146517A5086404914 @default.
• W2149146517 hasConcept C126322002 @default.
• W2149146517 hasConcept C134018914 @default.
• W2149146517 hasConcept C181199279 @default.
• W2149146517 hasConcept C185592680 @default.
• W2149146517 hasConcept C203014093 @default.
• W2149146517 hasConcept C2776417487 @default.
• W2149146517 hasConcept C2777318727 @default.
• W2149146517 hasConcept C2778004101 @default.
• W2149146517 hasConcept C2778102346 @default.
• W2149146517 hasConcept C2780795997 @default.
• W2149146517 hasConcept C2780829032 @default.
• W2149146517 hasConcept C2781116151 @default.
• W2149146517 hasConcept C519581460 @default.
• W2149146517 hasConcept C538909803 @default.
• W2149146517 hasConcept C55493867 @default.
• W2149146517 hasConcept C71924100 @default.
• W2149146517 hasConcept C86803240 @default.
• W2149146517 hasConceptScore W2149146517C126322002 @default.
• W2149146517 hasConceptScore W2149146517C134018914 @default.
• W2149146517 hasConceptScore W2149146517C181199279 @default.
• W2149146517 hasConceptScore W2149146517C185592680 @default.
• W2149146517 hasConceptScore W2149146517C203014093 @default.
• W2149146517 hasConceptScore W2149146517C2776417487 @default.
• W2149146517 hasConceptScore W2149146517C2777318727 @default.
• W2149146517 hasConceptScore W2149146517C2778004101 @default.
• W2149146517 hasConceptScore W2149146517C2778102346 @default.
• W2149146517 hasConceptScore W2149146517C2780795997 @default.
• W2149146517 hasConceptScore W2149146517C2780829032 @default.
• W2149146517 hasConceptScore W2149146517C2781116151 @default.
• W2149146517 hasConceptScore W2149146517C519581460 @default.
• W2149146517 hasConceptScore W2149146517C538909803 @default.
• W2149146517 hasConceptScore W2149146517C55493867 @default.

• next