Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149146541> ?p ?o ?g. }
- W2149146541 endingPage "1754" @default.
- W2149146541 startingPage "1743" @default.
- W2149146541 abstract "The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus erythematosus are largely unknown, although animal studies indicate that nuclear factor (NF)-κB is involved. We reported previously that a knockin mouse expressing an inactive form of ABIN1 (ABIN1[D485N]) develops lupus-like autoimmune disease and demonstrates enhanced activation of NF-κB and mitogen-activated protein kinases in immune cells after toll-like receptor stimulation. In the current study, we show that ABIN1[D485N] mice develop progressive GN similar to class III and IV lupus nephritis in humans. To investigate the clinical relevance of ABIN1 dysfunction, we genotyped five single-nucleotide polymorphisms in the gene encoding ABIN1, TNIP1, in samples from European-American, African American, Asian, Gullah, and Hispanic participants in the Large Lupus Association Study 2. Comparing cases of systemic lupus erythematosus with nephritis and cases of systemic lupus erythematosus without nephritis revealed strong associations with lupus nephritis at rs7708392 in European Americans and rs4958881 in African Americans. Comparing cases of systemic lupus erythematosus with nephritis and healthy controls revealed a stronger association at rs7708392 in European Americans but not at rs4958881 in African Americans. Our data suggest that variants in the TNIP1 gene are associated with the risk for lupus nephritis and could be mechanistically involved in disease development via aberrant regulation of NF-κB and mitogen-activated protein kinase activity." @default.
- W2149146541 created "2016-06-24" @default.
- W2149146541 creator A5007576322 @default.
- W2149146541 creator A5010072602 @default.
- W2149146541 creator A5010890113 @default.
- W2149146541 creator A5011480199 @default.
- W2149146541 creator A5014962817 @default.
- W2149146541 creator A5017873670 @default.
- W2149146541 creator A5020213104 @default.
- W2149146541 creator A5020753736 @default.
- W2149146541 creator A5023217115 @default.
- W2149146541 creator A5025774056 @default.
- W2149146541 creator A5030650722 @default.
- W2149146541 creator A5031240634 @default.
- W2149146541 creator A5032199338 @default.
- W2149146541 creator A5032779152 @default.
- W2149146541 creator A5036124130 @default.
- W2149146541 creator A5036191609 @default.
- W2149146541 creator A5036220201 @default.
- W2149146541 creator A5037897177 @default.
- W2149146541 creator A5038324495 @default.
- W2149146541 creator A5038541433 @default.
- W2149146541 creator A5041270389 @default.
- W2149146541 creator A5046081475 @default.
- W2149146541 creator A5051051572 @default.
- W2149146541 creator A5052053321 @default.
- W2149146541 creator A5052973247 @default.
- W2149146541 creator A5054680196 @default.
- W2149146541 creator A5055050710 @default.
- W2149146541 creator A5056255167 @default.
- W2149146541 creator A5057078399 @default.
- W2149146541 creator A5057776590 @default.
- W2149146541 creator A5060361210 @default.
- W2149146541 creator A5061226924 @default.
- W2149146541 creator A5062742878 @default.
- W2149146541 creator A5062745334 @default.
- W2149146541 creator A5064296895 @default.
- W2149146541 creator A5066883334 @default.
- W2149146541 creator A5068498766 @default.
- W2149146541 creator A5075555643 @default.
- W2149146541 creator A5082388906 @default.
- W2149146541 creator A5082825997 @default.
- W2149146541 creator A5083909928 @default.
- W2149146541 creator A5085769049 @default.
- W2149146541 creator A5087036525 @default.
- W2149146541 creator A5088206527 @default.
- W2149146541 creator A5090500376 @default.
- W2149146541 date "2013-11-01" @default.
- W2149146541 modified "2023-10-06" @default.
- W2149146541 title "ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis" @default.
- W2149146541 cites W1822745879 @default.
- W2149146541 cites W1964962218 @default.
- W2149146541 cites W1976454210 @default.
- W2149146541 cites W1989791234 @default.
- W2149146541 cites W2001115778 @default.
- W2149146541 cites W2003742101 @default.
- W2149146541 cites W2006535221 @default.
- W2149146541 cites W2008646773 @default.
- W2149146541 cites W2009749435 @default.
- W2149146541 cites W2010220327 @default.
- W2149146541 cites W2031580483 @default.
- W2149146541 cites W2032195857 @default.
- W2149146541 cites W2033562377 @default.
- W2149146541 cites W2037368171 @default.
- W2149146541 cites W2038527699 @default.
- W2149146541 cites W2045022575 @default.
- W2149146541 cites W2045113343 @default.
- W2149146541 cites W2045991166 @default.
- W2149146541 cites W2049572499 @default.
- W2149146541 cites W2051569082 @default.
- W2149146541 cites W2055581363 @default.
- W2149146541 cites W2064396641 @default.
- W2149146541 cites W2070527591 @default.
- W2149146541 cites W2070782085 @default.
- W2149146541 cites W2073027199 @default.
- W2149146541 cites W2073453659 @default.
- W2149146541 cites W2083333719 @default.
- W2149146541 cites W2085637098 @default.
- W2149146541 cites W2091695331 @default.
- W2149146541 cites W2104167564 @default.
- W2149146541 cites W2108214367 @default.
- W2149146541 cites W2110895642 @default.
- W2149146541 cites W2111312476 @default.
- W2149146541 cites W2111940985 @default.
- W2149146541 cites W2112653875 @default.
- W2149146541 cites W2115027287 @default.
- W2149146541 cites W2121652706 @default.
- W2149146541 cites W2124343538 @default.
- W2149146541 cites W2125548716 @default.
- W2149146541 cites W2126185185 @default.
- W2149146541 cites W2129242841 @default.
- W2149146541 cites W2132991384 @default.
- W2149146541 cites W2133899217 @default.
- W2149146541 cites W2134760231 @default.
- W2149146541 cites W2135717045 @default.
- W2149146541 cites W2138889351 @default.
- W2149146541 cites W2144589914 @default.
- W2149146541 cites W2147086116 @default.