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- W2149148768 abstract "to determine the prevalence of orthostatic hypotension (OH) and associations with medication use in community-dwelling older women.cross-sectional analysis using data from the British Women's Heart and Health Study.general practices in 23 towns in the UK.3,775 women aged 60-80 years from 1999 to 2001.orthostatic hypotension-drop of > or =20 mmHg in systolic and/or a drop of > or =10 mmHg in diastolic blood pressure on standing.prevalence of OH was 28% (95% confidence interval [CI] 26.6, 29.4), which increased with age and hypertension. Regardless of treatment status or diagnosed hypertension, raised blood pressure was strongly associated with OH (P < 0.001). OH was strongly associated with number of antihypertensives taken (none vs three or more: odds ratio [OR] 2.24, 95% CI 1.47-3.40, P < 0.001); the association was slightly attenuated after allowing for age and co-morbidities (OR 1.99; 95% CI 1.30, 3.05; P = 0.003). Women with multiple co-morbidities had markedly increased odds of OH independent of age, number and type of medications taken (none vs four or more diagnoses: OR 2.28, 95% CI 1.58-3.30, P = 0.005).uncontrolled hypertension, use of three or more antihypertensives and multiple co-morbidities are predictors of OH in older women. Detection or monitoring of OH in these groups may prevent women from suffering its adverse consequences." @default.
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- W2149148768 date "2009-11-06" @default.
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- W2149148768 title "The association between orthostatic hypotension and medication use in the British Women's Heart and Health Study" @default.
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- W2149148768 doi "https://doi.org/10.1093/ageing/afp192" @default.
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