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• W2149156948 endingPage "574" @default.
• W2149156948 startingPage "565" @default.
• W2149156948 abstract "Cannabinoid CB1 antagonists/inverse agonists suppress food-motivated behaviors and are being evaluated as potential appetite suppressants. It has been suggested that the effects of CB1 antagonism on food motivation could be related to actions on mesolimbic dopamine (DA). If this were true, then the effects of interference with cannabinoid CB1 transmission should closely resemble the effects of interference with DA transmission. To directly compare the effects of DA antagonists with those of CB1 antagonists/inverse agonists, the present studies employed a concurrent lever-pressing/chow-intake procedure. With this task, interference with DA transmission shifts choice behavior such that lever pressing for a preferred food is decreased but chow intake is increased. Rats treated with IP injections of the DA D1 antagonist SCH39166 (ecopipam; 0.05–0.2 mg/kg) or the D2 antagonist eticlopride (0.025–0.1 mg/kg) showed substantial decreases in lever pressing and concomitant increases in chow consumption. In contrast, IP administration of the CB1 neutral antagonist AM4113 (4.0–16.0 mg/kg) or the CB1 antagonist/inverse agonist AM251 (2.0–8.0 mg/kg) decreased operant responding for pellets, but there was no corresponding increase in chow intake. These effects of CB1 antagonists/inverse agonists were similar to those produced by the appetite suppressant fenfluramine and by prefeeding. In contrast, low doses of DA antagonists leave primary food motivation intact, but shift behaviors toward food reinforcers that can be obtained with lower response costs. These results suggest that the effects of interference with CB1 transmission are readily distinguishable from those of reduced DA transmission." @default.
• W2149156948 created "2016-06-24" @default.
• W2149156948 creator A5000540926 @default.
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• W2149156948 creator A5029694891 @default.
• W2149156948 creator A5039663365 @default.
• W2149156948 creator A5059365702 @default.
• W2149156948 date "2007-11-15" @default.
• W2149156948 modified "2023-10-09" @default.
• W2149156948 title "Cannabinoid CB1 antagonists and dopamine antagonists produce different effects on a task involving response allocation and effort-related choice in food-seeking behavior" @default.
• W2149156948 cites W1491109154 @default.
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• W2149156948 cites W1682243858 @default.
• W2149156948 cites W1952839444 @default.
• W2149156948 cites W1963482720 @default.
• W2149156948 cites W1963623154 @default.
• W2149156948 cites W1965679449 @default.
• W2149156948 cites W1966891940 @default.
• W2149156948 cites W1967039863 @default.
• W2149156948 cites W1967074973 @default.
• W2149156948 cites W1968490092 @default.
• W2149156948 cites W1975347776 @default.
• W2149156948 cites W1975748753 @default.
• W2149156948 cites W1977256878 @default.
• W2149156948 cites W1978245181 @default.
• W2149156948 cites W1983721187 @default.
• W2149156948 cites W1985771124 @default.
• W2149156948 cites W1986818311 @default.
• W2149156948 cites W1990949546 @default.
• W2149156948 cites W1991778481 @default.
• W2149156948 cites W1993631201 @default.
• W2149156948 cites W1998145889 @default.
• W2149156948 cites W2001109168 @default.
• W2149156948 cites W2002321040 @default.
• W2149156948 cites W2005383811 @default.
• W2149156948 cites W2007586845 @default.
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• W2149156948 cites W2013349633 @default.
• W2149156948 cites W2016017780 @default.
• W2149156948 cites W2016114488 @default.
• W2149156948 cites W2021420088 @default.
• W2149156948 cites W2024270031 @default.
• W2149156948 cites W2029820981 @default.
• W2149156948 cites W2031498785 @default.
• W2149156948 cites W2031570817 @default.
• W2149156948 cites W2033646971 @default.
• W2149156948 cites W2033818328 @default.
• W2149156948 cites W2034331584 @default.
• W2149156948 cites W2037730619 @default.
• W2149156948 cites W2046083062 @default.
• W2149156948 cites W2049876674 @default.
• W2149156948 cites W2051731235 @default.
• W2149156948 cites W2054475627 @default.
• W2149156948 cites W2054737044 @default.
• W2149156948 cites W2055018246 @default.
• W2149156948 cites W2055049966 @default.
• W2149156948 cites W2056240320 @default.
• W2149156948 cites W2059535381 @default.
• W2149156948 cites W2064885604 @default.
• W2149156948 cites W2069600955 @default.
• W2149156948 cites W2075604288 @default.
• W2149156948 cites W2083270036 @default.
• W2149156948 cites W2085314208 @default.
• W2149156948 cites W2085685449 @default.
• W2149156948 cites W2086135986 @default.
• W2149156948 cites W2113365852 @default.
• W2149156948 cites W2114207481 @default.
• W2149156948 cites W2116322199 @default.
• W2149156948 cites W2119458823 @default.
• W2149156948 cites W2124733378 @default.
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• W2149156948 cites W2168128112 @default.
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• W2149156948 doi "https://doi.org/10.1007/s00213-007-0988-4" @default.
• W2149156948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3713618" @default.
• W2149156948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18004546" @default.
• W2149156948 hasPublicationYear "2007" @default.
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