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- W2149160705 abstract "Assessment of promoter methylation of the O 6 -methylguanine DNA methyltransferase (MGMT) gene has recently gained importance in molecular profiling of high-grade gliomas. It has emerged not only as an important prognostic marker but also as a predictive marker for response to temozolomide in patients with newly diagnosed glioblastoma. Further, recent studies indicate that MGMT promoter methylation has strong prognostic relevance even in anaplastic (grade III) gliomas, irrespective of therapy (chemotherapy or radiotherapy). This article provides an overview of its use as a predictive and prognostic biomarker, as well as the methods employed for its assessment and use in therapeutic decision making." @default.
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- W2149160705 date "2011-01-01" @default.
- W2149160705 modified "2023-09-23" @default.
- W2149160705 title "O<sup>6</sup>-methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: A review of current status" @default.
- W2149160705 cites W2328946792 @default.
- W2149160705 doi "https://doi.org/10.4103/0028-3886.79128" @default.
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