FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149162518> ?p ?o ?g. }

• W2149162518 abstract "The proper functioning of the placenta requires specific patterns of methylation and the appropriate regulation of retroelements, some of which have been co-opted by the genome for placental-specific gene expression. Our inquiry was initiated to determine the causes of the placental defects observed in crosses between two species of mouse, Mus musculus and Mus caroli. M. musculus × M. caroli fetuses are rarely carried to term, possibly as a result of genomic incompatibility in the placenta. Taking into account that placental dysplasia is observed in Peromyscus and other Mus hybrids, and that endogenous retroviruses are expressed in the placental transcriptome, we hypothesized that these placental defects could result, in part, from failure of the genome defense mechanism, DNA methylation, to regulate the expression of retroelements. Hybrid M. musculus × M. caroli embryos were produced by artificial insemination, and dysplastic placentas were subjected to microarray and methylation screens. Aberrant overexpression of an X-linked Mus retroelement in these hybrid placentas is consistent with local demethylation of this retroelement, concomitant with genome instability, disruption of gene regulatory pathways, and dysgenesis. We propose that the placenta is a specific site of control that is disrupted by demethylation and retroelement activation in interspecific hybridization that occur as a result of species incompatibility of methylation machinery. To our knowledge, the present data provide the first report of retroelement activation linked to decreased methylation in a eutherian hybrid system." @default.
• W2149162518 created "2016-06-24" @default.
• W2149162518 creator A5015873205 @default.
• W2149162518 creator A5062980119 @default.
• W2149162518 creator A5080577891 @default.
• W2149162518 date "2012-03-01" @default.
• W2149162518 modified "2023-10-02" @default.
• W2149162518 title "Retroelement Demethylation Associated with Abnormal Placentation in Mus musculus × Mus caroli Hybrids1" @default.
• W2149162518 cites W1487807011 @default.
• W2149162518 cites W1491910236 @default.
• W2149162518 cites W1511049587 @default.
• W2149162518 cites W1518764691 @default.
• W2149162518 cites W1547343372 @default.
• W2149162518 cites W1631803961 @default.
• W2149162518 cites W1757699132 @default.
• W2149162518 cites W1967947923 @default.
• W2149162518 cites W1969907196 @default.
• W2149162518 cites W1972983329 @default.
• W2149162518 cites W1973443938 @default.
• W2149162518 cites W1976342457 @default.
• W2149162518 cites W1976844797 @default.
• W2149162518 cites W1981662437 @default.
• W2149162518 cites W1989644272 @default.
• W2149162518 cites W1989730522 @default.
• W2149162518 cites W1990381590 @default.
• W2149162518 cites W1993459732 @default.
• W2149162518 cites W1994865551 @default.
• W2149162518 cites W1995311901 @default.
• W2149162518 cites W1996060466 @default.
• W2149162518 cites W2000811509 @default.
• W2149162518 cites W2000941677 @default.
• W2149162518 cites W2002878335 @default.
• W2149162518 cites W2002901290 @default.
• W2149162518 cites W2003515720 @default.
• W2149162518 cites W2008122642 @default.
• W2149162518 cites W2016022730 @default.
• W2149162518 cites W2016097661 @default.
• W2149162518 cites W2016324446 @default.
• W2149162518 cites W2017936139 @default.
• W2149162518 cites W2020887634 @default.
• W2149162518 cites W2021122622 @default.
• W2149162518 cites W2032867057 @default.
• W2149162518 cites W2035173149 @default.
• W2149162518 cites W2037842315 @default.
• W2149162518 cites W2043622843 @default.
• W2149162518 cites W2047194869 @default.
• W2149162518 cites W2048070053 @default.
• W2149162518 cites W2061729961 @default.
• W2149162518 cites W2062093164 @default.
• W2149162518 cites W2063829263 @default.
• W2149162518 cites W2066487396 @default.
• W2149162518 cites W2074882879 @default.
• W2149162518 cites W2076159142 @default.
• W2149162518 cites W2077053535 @default.
• W2149162518 cites W2077906468 @default.
• W2149162518 cites W2084304758 @default.
• W2149162518 cites W2090453906 @default.
• W2149162518 cites W2090570458 @default.
• W2149162518 cites W2091601960 @default.
• W2149162518 cites W2093210519 @default.
• W2149162518 cites W2097186152 @default.
• W2149162518 cites W2103757755 @default.
• W2149162518 cites W2108244474 @default.
• W2149162518 cites W2112017997 @default.
• W2149162518 cites W2120151566 @default.
• W2149162518 cites W2121083017 @default.
• W2149162518 cites W2122403442 @default.
• W2149162518 cites W2122683221 @default.
• W2149162518 cites W2131067812 @default.
• W2149162518 cites W2133507029 @default.
• W2149162518 cites W2139122477 @default.
• W2149162518 cites W2140576705 @default.
• W2149162518 cites W2144026073 @default.
• W2149162518 cites W2146264881 @default.
• W2149162518 cites W2146523791 @default.
• W2149162518 cites W2151578754 @default.
• W2149162518 cites W2161584400 @default.
• W2149162518 cites W2163636924 @default.
• W2149162518 cites W2164773932 @default.
• W2149162518 cites W2228659042 @default.
• W2149162518 doi "https://doi.org/10.1095/biolreprod.111.095273" @default.
• W2149162518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22116807" @default.
• W2149162518 hasPublicationYear "2012" @default.
• W2149162518 type Work @default.
• W2149162518 sameAs 2149162518 @default.
• W2149162518 citedByCount "20" @default.
• W2149162518 countsByYear W21491625182012 @default.
• W2149162518 countsByYear W21491625182013 @default.
• W2149162518 countsByYear W21491625182014 @default.
• W2149162518 countsByYear W21491625182015 @default.
• W2149162518 countsByYear W21491625182016 @default.
• W2149162518 countsByYear W21491625182018 @default.
• W2149162518 countsByYear W21491625182019 @default.
• W2149162518 countsByYear W21491625182020 @default.
• W2149162518 countsByYear W21491625182021 @default.
• W2149162518 countsByYear W21491625182022 @default.
• W2149162518 crossrefType "journal-article" @default.
• W2149162518 hasAuthorship W2149162518A5015873205 @default.
• W2149162518 hasAuthorship W2149162518A5062980119 @default.
• W2149162518 hasAuthorship W2149162518A5080577891 @default.

• next