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- W2149166498 endingPage "S4" @default.
- W2149166498 startingPage "S4" @default.
- W2149166498 abstract "Renal cell carcinoma (RCC) accounts for approximately 2.6% of all cancers in the United States. While early stage disease is curable by surgery, the median survival of metastatic disease is only 13 months. In the last decade, there has been considerable progress in understanding the genetics of RCC. The VHL tumor suppressor gene is inactivated in the majority of RCC cases. The VHL protein (pVHL) acts as an E3 ligase that targets HIF-1, the hypoxia inducible transcription factor, for degradation by the ubiquitin proteasome system (UPS). In RCC cases with mutant pVHL, HIF-1 is stabilized and aberrantly expressed in normoxia, leading to the activation of pro-survival genes such as vascular endothelial growth factor (VEGF). This review will focus on the defect in the UPS that underlies RCC and describe the development of novel therapies that target the UPS. Publication history: Republished from Current BioData's Targeted Proteins database (TPdb; http://www.targetedproteinsdb.com)." @default.
- W2149166498 created "2016-06-24" @default.
- W2149166498 creator A5062740919 @default.
- W2149166498 date "2007-01-01" @default.
- W2149166498 modified "2023-10-16" @default.
- W2149166498 title "Role of the ubiquitin proteasome system in renal cell carcinoma" @default.
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