FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149167516> ?p ?o ?g. }

• W2149167516 endingPage "215" @default.
• W2149167516 startingPage "209" @default.
• W2149167516 abstract "Our aim was to quantify thromboxane B2 (TXB2) in umbilical cord serum of term infants of nulliparous, low-risk women who were randomly assigned to either placebo or low-dose (60 mg) aspirin (ASA) on a daily basis from 24 weeks' gestation through delivery as part of a randomized clinical trial for prevention of preeclampsia.Umbilical cord sera from 230 singleton, term infants whose mothers were involved in our low-dose ASA trial were assayed for TXB2, the stable metabolite of thromboxane A2, without knowledge of treatment or outcome data. The data were related to assigned treatment group, longitudinal pattern of maternal serum TXB2 levels, and other maternal and newborn characteristics. The data also were analyzed according to whether or not maternal serum levels of TXB2 at 29-31, 34-36, and delivery were reduced > or =50% compared to values prior to initiation of the trial.Umbilical cord TXB2 levels (ng/ml, mean +/- SE) were significantly lower at term in the ASA group (36.1 +/- 3.3, n = 111) than in the placebo group (56.6 +/- 5.7, n = 119; P = 0.002). Umbilical cord TXB2 levels were correlated to those in maternal serum at delivery in the ASA group (r = 0.3441; P = 0.0005) but not in the placebo group (r = 0.0626; P = 0.53). Regardless of assigned treatment group, infants whose mothers had a > or =50% longitudinal reduction in serum TXB2 had lower umbilical cord TXB2 levels (39.2 +/- 3.6, n = 114) than infants whose mothers had <50% reductions in TXB2 (54.6 +/- 5.9, n = 116; P = 0.027). Birthweights of these infants correlated inversely (r = 0.1678, P = 0.017) with maternal serum TXB2 at delivery but not to umbilical cord TXB2 levels; the best correlation between birthweight and maternal serum TXB2 was noted in pregnancies assigned to receive placebo (r = -0.2558, P = 0.009).Umbilical cord serum levels of TXB2 1) are reduced in instances of long-term maternal ingestion of ASA, 2) correlate well with maternal serum levels of TXB2 at delivery when there is evidence for consistent maternal use of ASA, but 3) do not correlate with maternal serum TXB2 levels when there is no evidence for frequent maternal ingestion of cyclooxygenase inhibitors. These data suggest that the capacity for platelet production of TXA2 in fetal and maternal compartments are regulated independently. Finally, there is an inverse relationship between maternal serum TXB2 levels at delivery and birthweight of newborn infants that is most evident among the pregnancies assigned to placebo and also among pregnancies in which there was little evidence to suggest a pattern of cyclooxygenase inhibitor use during pregnancy." @default.
• W2149167516 created "2016-06-24" @default.
• W2149167516 creator A5010939419 @default.
• W2149167516 creator A5056155514 @default.
• W2149167516 creator A5061269721 @default.
• W2149167516 creator A5065331586 @default.
• W2149167516 creator A5081259784 @default.
• W2149167516 date "2000-01-01" @default.
• W2149167516 modified "2023-09-26" @default.
• W2149167516 title "Umbilical cord serum levels of thromboxane B2 in term infants of women who participated in a placebo-controlled trial of low-dose aspirin" @default.
• W2149167516 cites W1502848733 @default.
• W2149167516 cites W1965653167 @default.
• W2149167516 cites W1973459042 @default.
• W2149167516 cites W1985001641 @default.
• W2149167516 cites W1985793416 @default.
• W2149167516 cites W2000857693 @default.
• W2149167516 cites W2002269694 @default.
• W2149167516 cites W200459668 @default.
• W2149167516 cites W2013829435 @default.
• W2149167516 cites W2017294539 @default.
• W2149167516 cites W2021879241 @default.
• W2149167516 cites W2039458448 @default.
• W2149167516 cites W2048260363 @default.
• W2149167516 cites W2049556573 @default.
• W2149167516 cites W2065342543 @default.
• W2149167516 cites W2069910182 @default.
• W2149167516 cites W2092632618 @default.
• W2149167516 cites W2095470682 @default.
• W2149167516 cites W2139257768 @default.
• W2149167516 cites W2340870097 @default.
• W2149167516 cites W2470097850 @default.
• W2149167516 cites W3023719646 @default.
• W2149167516 doi "https://doi.org/10.1002/1520-6661(200007/08)9:4<209::aid-mfm4>3.0.co;2-s" @default.
• W2149167516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11048830" @default.
• W2149167516 hasPublicationYear "2000" @default.
• W2149167516 type Work @default.
• W2149167516 sameAs 2149167516 @default.
• W2149167516 citedByCount "9" @default.
• W2149167516 countsByYear W21491675162013 @default.
• W2149167516 countsByYear W21491675162015 @default.
• W2149167516 countsByYear W21491675162017 @default.
• W2149167516 countsByYear W21491675162019 @default.
• W2149167516 countsByYear W21491675162020 @default.
• W2149167516 countsByYear W21491675162022 @default.
• W2149167516 crossrefType "journal-article" @default.
• W2149167516 hasAuthorship W2149167516A5010939419 @default.
• W2149167516 hasAuthorship W2149167516A5056155514 @default.
• W2149167516 hasAuthorship W2149167516A5061269721 @default.
• W2149167516 hasAuthorship W2149167516A5065331586 @default.
• W2149167516 hasAuthorship W2149167516A5081259784 @default.
• W2149167516 hasConcept C126322002 @default.
• W2149167516 hasConcept C131872663 @default.
• W2149167516 hasConcept C142724271 @default.
• W2149167516 hasConcept C168563851 @default.
• W2149167516 hasConcept C203014093 @default.
• W2149167516 hasConcept C204787440 @default.
• W2149167516 hasConcept C27081682 @default.
• W2149167516 hasConcept C2776785769 @default.
• W2149167516 hasConcept C2776955114 @default.
• W2149167516 hasConcept C2777218350 @default.
• W2149167516 hasConcept C2777628954 @default.
• W2149167516 hasConcept C2779234561 @default.
• W2149167516 hasConcept C2781080829 @default.
• W2149167516 hasConcept C42219234 @default.
• W2149167516 hasConcept C46973012 @default.
• W2149167516 hasConcept C54355233 @default.
• W2149167516 hasConcept C71924100 @default.
• W2149167516 hasConcept C86803240 @default.
• W2149167516 hasConcept C89560881 @default.
• W2149167516 hasConceptScore W2149167516C126322002 @default.
• W2149167516 hasConceptScore W2149167516C131872663 @default.
• W2149167516 hasConceptScore W2149167516C142724271 @default.
• W2149167516 hasConceptScore W2149167516C168563851 @default.
• W2149167516 hasConceptScore W2149167516C203014093 @default.
• W2149167516 hasConceptScore W2149167516C204787440 @default.
• W2149167516 hasConceptScore W2149167516C27081682 @default.
• W2149167516 hasConceptScore W2149167516C2776785769 @default.
• W2149167516 hasConceptScore W2149167516C2776955114 @default.
• W2149167516 hasConceptScore W2149167516C2777218350 @default.
• W2149167516 hasConceptScore W2149167516C2777628954 @default.
• W2149167516 hasConceptScore W2149167516C2779234561 @default.
• W2149167516 hasConceptScore W2149167516C2781080829 @default.
• W2149167516 hasConceptScore W2149167516C42219234 @default.
• W2149167516 hasConceptScore W2149167516C46973012 @default.
• W2149167516 hasConceptScore W2149167516C54355233 @default.
• W2149167516 hasConceptScore W2149167516C71924100 @default.
• W2149167516 hasConceptScore W2149167516C86803240 @default.
• W2149167516 hasConceptScore W2149167516C89560881 @default.
• W2149167516 hasIssue "4" @default.
• W2149167516 hasLocation W21491675161 @default.
• W2149167516 hasLocation W21491675162 @default.
• W2149167516 hasOpenAccess W2149167516 @default.
• W2149167516 hasPrimaryLocation W21491675161 @default.
• W2149167516 hasRelatedWork W1972705490 @default.
• W2149167516 hasRelatedWork W1985793416 @default.
• W2149167516 hasRelatedWork W1991627561 @default.
• W2149167516 hasRelatedWork W2001340498 @default.
• W2149167516 hasRelatedWork W2010172307 @default.

• next