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• W2149169526 abstract "Abstract The structurally and pharmacologically intriguing but stereochemically initially disregarded small class of biarylic biscarbazole alkaloids is presented, starting with an introduction of the different structural patterns found in nature. For the construction of the biaryl bond, mainly biomimetic oxidative coupling reactions were used, as shown for the natural products bismurrayaquinone‐A, bis‐2‐hydroxy‐3‐methylcarbazole, clausenamine‐A, and murrastifoline‐F. For most of these compounds, a resolution of the respective atropo‐enantiomers succeeded either directly, by high‐performance liquid chromatography by HPLC on a chiral phase, or via atropo‐diastereomers, after derivatization with a chiral auxiliary. The absolute configurations of the pure enantiomers were assigned by comparison of experimental (CD) spectra with those quantum chemi‐cally calculated, or, for atropo‐diastereomeric derivatives, by means of ROESY investigations and X‐ray crystallography. Ullmann‐type coupling conditions were also found to be feasible for the construction of the 2,2′‐biscarbazole core, necessitating a completely regioselective 2‐bromination protocol. The first atroposelective synthesis of such a basic target structure was achieved by application of the “lactone methodology,” giving rise to an atropisomeric ratio of 85 : 15. Some of the biscarbazole alkaloids and their derivatives were found to have interesting bioactivities, and for the first time, the natural atropo‐enantiomeric ratio in the plants was determined for one of these compounds, murrastifoline‐F. ©2002 The Japan Chemical Journal Forum and Wiley Periodicals, Inc. Chem Rec 2:113–126, 2002: Published online in Wiley InterScience (www.interscience.wiley.com) DOI 10.1002/tcr.10014" @default.
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• W2149169526 date "2002-03-01" @default.
• W2149169526 modified "2023-10-14" @default.
• W2149169526 title "Biarylic Biscarbazole Alkaloids: Occurrence, Stereochemistry, Synthesis, and Bioactivity" @default.
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• W2149169526 doi "https://doi.org/10.1002/tcr.10014" @default.
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