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• W2149172695 startingPage "6344" @default.
• W2149172695 abstract "The Myc transcription factor plays a central role in the regulation of cell cycle progression, apoptosis, angiogenesis, and cellular transformation. Myc is a potent oncoprotein that is deregulated in a wide variety of human tumors and is therefore an attractive target for novel cancer therapies. Using a cellular screening approach, we have identified low-molecular-weight compounds, Myc pathway response agents (MYRAs), that induce apoptosis in a c-Myc-dependent manner and inhibit Myc-driven cellular transformation. MYRA-A inhibits Myc transactivation and interferes with the DNA-binding activity of Myc family proteins but has no effect on the E-box-binding protein USF. In contrast, MYRA-B induces Myc-dependent apoptosis without affecting Myc transactivation or Myc/Max DNA binding. Our data show that cellular screening assays can be a powerful strategy for the identification of candidate substances that modulate the Myc pathway. These compounds can be useful tools for studying Myc function and may also be of therapeutic potential as leads for drug development." @default.
• W2149172695 created "2016-06-24" @default.
• W2149172695 creator A5056646576 @default.
• W2149172695 creator A5077542341 @default.
• W2149172695 date "2006-04-18" @default.
• W2149172695 modified "2023-10-01" @default.
• W2149172695 title "Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation" @default.
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• W2149172695 doi "https://doi.org/10.1073/pnas.0601418103" @default.
• W2149172695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1435363" @default.
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• W2149172695 hasPublicationYear "2006" @default.
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