Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149173731> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2149173731 endingPage "322" @default.
- W2149173731 startingPage "313" @default.
- W2149173731 abstract "The time—response curve of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) concentrations in the striatum of the rat were measured during apomorphine, haloperidol, morphine, oxotremorine or reserpine treatment as well as after a brain lesion. The results showed that changes in DOPAC concentrations consistently preceded changes in HVA concentrations. It was concluded that HVA must be considered as a “second metabolite” rather than as a marker of extra-neuronal metabolism. The turnover of HVA calculated after tropolone treatment revealed that this compound can be considered as a reliable COMT inhibitor. The turnover of 3-methoxytyramine (3-MT) calculated after tropolone treatment (during MAO inhibition) appeared to be 1.9 nmol/g/h. From this relatively low value it was concluded that 3-MT cannot be considered as an alternative metabolite for DA degradation during MAO inhibition. 3-MT concentrations measured after apomorphine or γ-hydroxybutyric acid treatment also suggest that 3-MT leaves the brain to only a minor extent during MAO inhibition. The effects of reserpine on pargyline-induced 3-MT concentrations indicate that there is hardly any COMT-activity in dopaminergic terminals. Evidence was provided that, at least during reserpine or pargyline treatment, dopamine leaves the brain unmetabolized or via unknown metabolic pathways." @default.
- W2149173731 created "2016-06-24" @default.
- W2149173731 creator A5081307695 @default.
- W2149173731 date "1979-07-01" @default.
- W2149173731 modified "2023-10-16" @default.
- W2149173731 title "Further studies on the sequence of dopamine metabolism in the rat brain" @default.
- W2149173731 cites W1965953710 @default.
- W2149173731 cites W1991524987 @default.
- W2149173731 cites W1995792925 @default.
- W2149173731 cites W1997909574 @default.
- W2149173731 cites W2001858772 @default.
- W2149173731 cites W2018023984 @default.
- W2149173731 cites W2026087181 @default.
- W2149173731 cites W2045084618 @default.
- W2149173731 cites W2045690336 @default.
- W2149173731 cites W2075798306 @default.
- W2149173731 cites W2085872902 @default.
- W2149173731 cites W2088084074 @default.
- W2149173731 cites W2088333016 @default.
- W2149173731 cites W2091194040 @default.
- W2149173731 cites W2092301152 @default.
- W2149173731 cites W2110894929 @default.
- W2149173731 cites W2134194270 @default.
- W2149173731 cites W2276629573 @default.
- W2149173731 doi "https://doi.org/10.1016/0014-2999(79)90261-9" @default.
- W2149173731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/477727" @default.
- W2149173731 hasPublicationYear "1979" @default.
- W2149173731 type Work @default.
- W2149173731 sameAs 2149173731 @default.
- W2149173731 citedByCount "74" @default.
- W2149173731 countsByYear W21491737312012 @default.
- W2149173731 countsByYear W21491737312013 @default.
- W2149173731 countsByYear W21491737312017 @default.
- W2149173731 crossrefType "journal-article" @default.
- W2149173731 hasAuthorship W2149173731A5081307695 @default.
- W2149173731 hasConcept C126322002 @default.
- W2149173731 hasConcept C134018914 @default.
- W2149173731 hasConcept C137183658 @default.
- W2149173731 hasConcept C170493617 @default.
- W2149173731 hasConcept C178790620 @default.
- W2149173731 hasConcept C181199279 @default.
- W2149173731 hasConcept C185592680 @default.
- W2149173731 hasConcept C2775841634 @default.
- W2149173731 hasConcept C2775864247 @default.
- W2149173731 hasConcept C2775905480 @default.
- W2149173731 hasConcept C2776024655 @default.
- W2149173731 hasConcept C2777067607 @default.
- W2149173731 hasConcept C2777477808 @default.
- W2149173731 hasConcept C2777509971 @default.
- W2149173731 hasConcept C2777525119 @default.
- W2149173731 hasConcept C2777842393 @default.
- W2149173731 hasConcept C513476851 @default.
- W2149173731 hasConcept C55493867 @default.
- W2149173731 hasConcept C71924100 @default.
- W2149173731 hasConcept C86803240 @default.
- W2149173731 hasConcept C98274493 @default.
- W2149173731 hasConceptScore W2149173731C126322002 @default.
- W2149173731 hasConceptScore W2149173731C134018914 @default.
- W2149173731 hasConceptScore W2149173731C137183658 @default.
- W2149173731 hasConceptScore W2149173731C170493617 @default.
- W2149173731 hasConceptScore W2149173731C178790620 @default.
- W2149173731 hasConceptScore W2149173731C181199279 @default.
- W2149173731 hasConceptScore W2149173731C185592680 @default.
- W2149173731 hasConceptScore W2149173731C2775841634 @default.
- W2149173731 hasConceptScore W2149173731C2775864247 @default.
- W2149173731 hasConceptScore W2149173731C2775905480 @default.
- W2149173731 hasConceptScore W2149173731C2776024655 @default.
- W2149173731 hasConceptScore W2149173731C2777067607 @default.
- W2149173731 hasConceptScore W2149173731C2777477808 @default.
- W2149173731 hasConceptScore W2149173731C2777509971 @default.
- W2149173731 hasConceptScore W2149173731C2777525119 @default.
- W2149173731 hasConceptScore W2149173731C2777842393 @default.
- W2149173731 hasConceptScore W2149173731C513476851 @default.
- W2149173731 hasConceptScore W2149173731C55493867 @default.
- W2149173731 hasConceptScore W2149173731C71924100 @default.
- W2149173731 hasConceptScore W2149173731C86803240 @default.
- W2149173731 hasConceptScore W2149173731C98274493 @default.
- W2149173731 hasIssue "4" @default.
- W2149173731 hasLocation W21491737311 @default.
- W2149173731 hasLocation W21491737312 @default.
- W2149173731 hasOpenAccess W2149173731 @default.
- W2149173731 hasPrimaryLocation W21491737311 @default.
- W2149173731 hasRelatedWork W1973516930 @default.
- W2149173731 hasRelatedWork W1987311156 @default.
- W2149173731 hasRelatedWork W1992818207 @default.
- W2149173731 hasRelatedWork W2018023984 @default.
- W2149173731 hasRelatedWork W2028890590 @default.
- W2149173731 hasRelatedWork W2041668284 @default.
- W2149173731 hasRelatedWork W2046454822 @default.
- W2149173731 hasRelatedWork W2089103546 @default.
- W2149173731 hasRelatedWork W2149173731 @default.
- W2149173731 hasRelatedWork W960106582 @default.
- W2149173731 hasVolume "56" @default.
- W2149173731 isParatext "false" @default.
- W2149173731 isRetracted "false" @default.
- W2149173731 magId "2149173731" @default.
- W2149173731 workType "article" @default.