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• W2149174578 abstract "Fragile X mental retardation syndrome, the most common form of inherited mental retardation, is caused by the absence of the fragile X mental retardation protein (FMRP). FMRP has been shown to use its arginine–glycine–glycine (RGG) box to bind to a subset of RNA targets that form a G quadruplex structure. We performed a detailed analysis of the interactions between the FMRP RGG box and the microtubule associated protein 1B (MAP1B) mRNA, a relevant in vivo FMRP target. We show that MAP1B RNA forms an intramolecular G quadruplex structure, which is bound with high affinity and specificity by the FMRP RGG box. We determined that hydrophobic interactions are important in the FMRP RGG box-MAP1B RNA association, with minor contributions from electrostatic interactions. Our findings that at low protein:RNA ratios the RNA G quadruplex structure is slightly stabilized, whereas at high ratios is unfolded, suggest a mechanism by which the FMRP concentration variation in response to a neurotransmitter stimulation event could act as a regulatory switch for the protein function, from translation repressor to translation activator." @default.
• W2149174578 created "2016-06-24" @default.
• W2149174578 creator A5040100614 @default.
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• W2149174578 date "2008-06-25" @default.
• W2149174578 modified "2023-10-17" @default.
• W2149174578 title "Fragile X mental retardation protein interactions with the microtubule associated protein 1B RNA" @default.
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• W2149174578 doi "https://doi.org/10.1261/rna.1100708" @default.
• W2149174578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2491469" @default.
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