FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149175059> ?p ?o ?g. }

• W2149175059 endingPage "4598" @default.
• W2149175059 startingPage "4589" @default.
• W2149175059 abstract "Structures of r(CGCGCG) 2 and 2′- O -Me(CGCGCG) 2 have been determined by NMR spectroscopy under low salt conditions. All protons and phosphorus nuclei resonances have been assigned. Signals of H5′/5″ have been assigned stereospecifically. All 3 J H,H and 3 J P,H coupling constants have been measured. The structures were determined and refined using an iterative relaxation matrix procedure (IRMA) and the restrained MD simulation. Both duplexes form half-turn, right-handed helices with several conformational features which deviate significantly from a canonical A-RNA structure. Duplexes are characterised as having C3′-endo sugar pucker, very low base-pair rise and high helical twist and inclination angles. Helices are overwound with <10 bp per turn. There is limited inter-strand guanine stacking for CG steps. Within CG steps of both duplexes, the planes of the inter-strand cytosines are not parallel while guanines are almost parallel. For the GC steps this pattern is reversed. The 2′- O -methyl groups are spatially close to the 5′-hydrogens of neighbouring residues from the 3′-side and are directed towards the minor groove of 2′- O -Me(CGCGCG) 2 forming a hydrophobic layer. Solution structures of both duplexes are similar; the effect of 2′- O -methylation on the parent RNA structure is small. This suggests that intrinsic properties imposed by alternating CG base pairs govern the overall conformation of both duplexes." @default.
• W2149175059 created "2016-06-24" @default.
• W2149175059 creator A5018487426 @default.
• W2149175059 creator A5027405458 @default.
• W2149175059 creator A5045574743 @default.
• W2149175059 creator A5066355029 @default.
• W2149175059 date "1997-11-15" @default.
• W2149175059 modified "2023-09-23" @default.
• W2149175059 title "Solution structure of RNA duplexes containing alternating CG base pairs: NMR study of r(CGCGCG)2 and 2'-O-Me(CGCGCG)2 under low salt conditions" @default.
• W2149175059 cites W1498439983 @default.
• W2149175059 cites W1571881198 @default.
• W2149175059 cites W1588834417 @default.
• W2149175059 cites W1970597920 @default.
• W2149175059 cites W1971017787 @default.
• W2149175059 cites W2024224587 @default.
• W2149175059 cites W2028735355 @default.
• W2149175059 cites W2033210811 @default.
• W2149175059 cites W2035186580 @default.
• W2149175059 cites W2038865588 @default.
• W2149175059 cites W2042933997 @default.
• W2149175059 cites W2050843661 @default.
• W2149175059 cites W2056519993 @default.
• W2149175059 cites W2059311617 @default.
• W2149175059 cites W2067557390 @default.
• W2149175059 cites W2077702860 @default.
• W2149175059 cites W2087003215 @default.
• W2149175059 cites W2094521817 @default.
• W2149175059 cites W2107353584 @default.
• W2149175059 cites W2154989302 @default.
• W2149175059 doi "https://doi.org/10.1093/nar/25.22.4589" @default.
• W2149175059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/147063" @default.
• W2149175059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9358170" @default.
• W2149175059 hasPublicationYear "1997" @default.
• W2149175059 type Work @default.
• W2149175059 sameAs 2149175059 @default.
• W2149175059 citedByCount "45" @default.
• W2149175059 countsByYear W21491750592012 @default.
• W2149175059 countsByYear W21491750592013 @default.
• W2149175059 countsByYear W21491750592014 @default.
• W2149175059 countsByYear W21491750592016 @default.
• W2149175059 countsByYear W21491750592018 @default.
• W2149175059 countsByYear W21491750592019 @default.
• W2149175059 countsByYear W21491750592020 @default.
• W2149175059 countsByYear W21491750592021 @default.
• W2149175059 countsByYear W21491750592023 @default.
• W2149175059 crossrefType "journal-article" @default.
• W2149175059 hasAuthorship W2149175059A5018487426 @default.
• W2149175059 hasAuthorship W2149175059A5027405458 @default.
• W2149175059 hasAuthorship W2149175059A5045574743 @default.
• W2149175059 hasAuthorship W2149175059A5066355029 @default.
• W2149175059 hasBestOaLocation W21491750591 @default.
• W2149175059 hasConcept C104317684 @default.
• W2149175059 hasConcept C121332964 @default.
• W2149175059 hasConcept C185581394 @default.
• W2149175059 hasConcept C185592680 @default.
• W2149175059 hasConcept C18903297 @default.
• W2149175059 hasConcept C2778301229 @default.
• W2149175059 hasConcept C2778530040 @default.
• W2149175059 hasConcept C2779965526 @default.
• W2149175059 hasConcept C33347731 @default.
• W2149175059 hasConcept C46141821 @default.
• W2149175059 hasConcept C512185932 @default.
• W2149175059 hasConcept C552990157 @default.
• W2149175059 hasConcept C55493867 @default.
• W2149175059 hasConcept C66974803 @default.
• W2149175059 hasConcept C67705224 @default.
• W2149175059 hasConcept C71240020 @default.
• W2149175059 hasConcept C8010536 @default.
• W2149175059 hasConcept C85641259 @default.
• W2149175059 hasConcept C86803240 @default.
• W2149175059 hasConceptScore W2149175059C104317684 @default.
• W2149175059 hasConceptScore W2149175059C121332964 @default.
• W2149175059 hasConceptScore W2149175059C185581394 @default.
• W2149175059 hasConceptScore W2149175059C185592680 @default.
• W2149175059 hasConceptScore W2149175059C18903297 @default.
• W2149175059 hasConceptScore W2149175059C2778301229 @default.
• W2149175059 hasConceptScore W2149175059C2778530040 @default.
• W2149175059 hasConceptScore W2149175059C2779965526 @default.
• W2149175059 hasConceptScore W2149175059C33347731 @default.
• W2149175059 hasConceptScore W2149175059C46141821 @default.
• W2149175059 hasConceptScore W2149175059C512185932 @default.
• W2149175059 hasConceptScore W2149175059C552990157 @default.
• W2149175059 hasConceptScore W2149175059C55493867 @default.
• W2149175059 hasConceptScore W2149175059C66974803 @default.
• W2149175059 hasConceptScore W2149175059C67705224 @default.
• W2149175059 hasConceptScore W2149175059C71240020 @default.
• W2149175059 hasConceptScore W2149175059C8010536 @default.
• W2149175059 hasConceptScore W2149175059C85641259 @default.
• W2149175059 hasConceptScore W2149175059C86803240 @default.
• W2149175059 hasIssue "22" @default.
• W2149175059 hasLocation W21491750591 @default.
• W2149175059 hasLocation W21491750592 @default.
• W2149175059 hasLocation W21491750593 @default.
• W2149175059 hasLocation W21491750594 @default.
• W2149175059 hasOpenAccess W2149175059 @default.
• W2149175059 hasPrimaryLocation W21491750591 @default.
• W2149175059 hasRelatedWork W2024044539 @default.
• W2149175059 hasRelatedWork W2072874868 @default.

• next