FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149182445> ?p ?o ?g. }

• W2149182445 endingPage "C1173" @default.
• W2149182445 startingPage "C1161" @default.
• W2149182445 abstract "Electrical activity is thought to be the primary neural stimulus regulating muscle mass, expression of myogenic regulatory factor genes, and cellular activity within skeletal muscle. However, the relative contribution of neural influences that are activity-dependent and -independent in modulating these characteristics is unclear. Comparisons of denervation (no neural influence) and spinal cord isolation (SI, neural influence with minimal activity) after 3, 14, and 28 days of treatment were used to demonstrate whether there are neural influences on muscle that are activity independent. Furthermore, the effects of these manipulations were compared for a fast ankle extensor (medial gastrocnemius) and a fast ankle flexor (tibialis anterior). The mass of both muscles plateaued at ∼60% of control 2 wk after SI, whereas both muscles progressively atrophied to <25% of initial mass at this same time point after denervation. A rapid increase in myogenin and, to a lesser extent, MyoD mRNAs and proteins was observed in denervated and SI muscles: at the later time points, these myogenic regulatory factors remained elevated in denervated, but not in SI, muscles. This widespread neural activity-independent influence on MyoD and myogenin expression was observed in myonuclei and satellite cells and was not specific for fast or slow fiber phenotypes. Mitotic activity of satellite and connective tissue cells also was consistently lower in SI than in denervated muscles. These results demonstrate a neural effect independent of electrical activity that 1) helps preserve muscle mass, 2) regulates muscle-specific genes, and 3) potentially spares the satellite cell pool in inactive muscles." @default.
• W2149182445 created "2016-06-24" @default.
• W2149182445 creator A5003699619 @default.
• W2149182445 creator A5041686634 @default.
• W2149182445 creator A5048468120 @default.
• W2149182445 creator A5068627403 @default.
• W2149182445 date "2003-11-01" @default.
• W2149182445 modified "2023-09-25" @default.
• W2149182445 title "Nerve activity-independent regulation of skeletal muscle atrophy: role of MyoD and myogenin in satellite cells and myonuclei" @default.
• W2149182445 cites W1729354010 @default.
• W2149182445 cites W176989354 @default.
• W2149182445 cites W1837450065 @default.
• W2149182445 cites W1899911036 @default.
• W2149182445 cites W1968796638 @default.
• W2149182445 cites W1973583835 @default.
• W2149182445 cites W1975572108 @default.
• W2149182445 cites W1975715507 @default.
• W2149182445 cites W1980008693 @default.
• W2149182445 cites W1985957785 @default.
• W2149182445 cites W1986792090 @default.
• W2149182445 cites W1992591328 @default.
• W2149182445 cites W1993230208 @default.
• W2149182445 cites W2012248913 @default.
• W2149182445 cites W2014835594 @default.
• W2149182445 cites W2015716179 @default.
• W2149182445 cites W2024946243 @default.
• W2149182445 cites W2025689336 @default.
• W2149182445 cites W2026026141 @default.
• W2149182445 cites W2030426416 @default.
• W2149182445 cites W2031017070 @default.
• W2149182445 cites W2035178522 @default.
• W2149182445 cites W2038474589 @default.
• W2149182445 cites W2040168630 @default.
• W2149182445 cites W2042283819 @default.
• W2149182445 cites W2044917078 @default.
• W2149182445 cites W2047371948 @default.
• W2149182445 cites W2052996043 @default.
• W2149182445 cites W2056586213 @default.
• W2149182445 cites W2057857889 @default.
• W2149182445 cites W2061287688 @default.
• W2149182445 cites W2061468579 @default.
• W2149182445 cites W2066137693 @default.
• W2149182445 cites W2074823600 @default.
• W2149182445 cites W2078256900 @default.
• W2149182445 cites W2080509056 @default.
• W2149182445 cites W2087999457 @default.
• W2149182445 cites W2094807296 @default.
• W2149182445 cites W2095158763 @default.
• W2149182445 cites W2100688137 @default.
• W2149182445 cites W2118162388 @default.
• W2149182445 cites W2121122019 @default.
• W2149182445 cites W2148240710 @default.
• W2149182445 cites W2148475063 @default.
• W2149182445 cites W2152315418 @default.
• W2149182445 cites W2152890178 @default.
• W2149182445 cites W2156565066 @default.
• W2149182445 cites W2161887020 @default.
• W2149182445 cites W2163548105 @default.
• W2149182445 cites W2167033587 @default.
• W2149182445 cites W2171906901 @default.
• W2149182445 cites W2184324819 @default.
• W2149182445 cites W2221784365 @default.
• W2149182445 cites W2231345824 @default.
• W2149182445 cites W2255700777 @default.
• W2149182445 cites W2285306797 @default.
• W2149182445 cites W2415143274 @default.
• W2149182445 doi "https://doi.org/10.1152/ajpcell.00128.2003" @default.
• W2149182445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12839833" @default.
• W2149182445 hasPublicationYear "2003" @default.
• W2149182445 type Work @default.
• W2149182445 sameAs 2149182445 @default.
• W2149182445 citedByCount "121" @default.
• W2149182445 countsByYear W21491824452012 @default.
• W2149182445 countsByYear W21491824452013 @default.
• W2149182445 countsByYear W21491824452014 @default.
• W2149182445 countsByYear W21491824452015 @default.
• W2149182445 countsByYear W21491824452016 @default.
• W2149182445 countsByYear W21491824452017 @default.
• W2149182445 countsByYear W21491824452018 @default.
• W2149182445 countsByYear W21491824452019 @default.
• W2149182445 countsByYear W21491824452020 @default.
• W2149182445 countsByYear W21491824452021 @default.
• W2149182445 countsByYear W21491824452022 @default.
• W2149182445 countsByYear W21491824452023 @default.
• W2149182445 crossrefType "journal-article" @default.
• W2149182445 hasAuthorship W2149182445A5003699619 @default.
• W2149182445 hasAuthorship W2149182445A5041686634 @default.
• W2149182445 hasAuthorship W2149182445A5048468120 @default.
• W2149182445 hasAuthorship W2149182445A5068627403 @default.
• W2149182445 hasConcept C105702510 @default.
• W2149182445 hasConcept C126322002 @default.
• W2149182445 hasConcept C134018914 @default.
• W2149182445 hasConcept C2776805190 @default.
• W2149182445 hasConcept C2778106681 @default.
• W2149182445 hasConcept C2779959927 @default.
• W2149182445 hasConcept C2780508455 @default.
• W2149182445 hasConcept C2909166674 @default.
• W2149182445 hasConcept C3763915 @default.

• next