Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149185747> ?p ?o ?g. }
- W2149185747 endingPage "2167" @default.
- W2149185747 startingPage "2159" @default.
- W2149185747 abstract "Defining signals that can support the self-renewal of multipotential hemopoietic progenitor cells (MHPCs) is pertinent to understanding leukemogenesis and may be relevant to developing stem cell-based therapies. Here we define a set of signals, JAK2 plus either c-kit or flt-3, which together can support extensive MHPC self-renewal. Phenotypically and functionally distinct populations of MHPCs were obtained, depending on which receptor tyrosine kinase, c-kit or flt-3, was activated. Self-renewal was abrogated in the absence of STAT5a/b, and in the presence of inhibitors targeting either the mitogen-activated protein kinase or phosphatidylinositol 3' kinase pathways. These findings suggest that a simple two-component signal can drive MHPC self-renewal." @default.
- W2149185747 created "2016-06-24" @default.
- W2149185747 creator A5005224886 @default.
- W2149185747 creator A5008851883 @default.
- W2149185747 creator A5020985624 @default.
- W2149185747 creator A5027179598 @default.
- W2149185747 creator A5032330582 @default.
- W2149185747 creator A5059611399 @default.
- W2149185747 creator A5059930066 @default.
- W2149185747 creator A5063440051 @default.
- W2149185747 creator A5066150656 @default.
- W2149185747 creator A5068336316 @default.
- W2149185747 creator A5077797768 @default.
- W2149185747 creator A5083290776 @default.
- W2149185747 date "2002-05-01" @default.
- W2149185747 modified "2023-10-14" @default.
- W2149185747 title "JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells" @default.
- W2149185747 cites W134922517 @default.
- W2149185747 cites W1488192600 @default.
- W2149185747 cites W1504115723 @default.
- W2149185747 cites W154122761 @default.
- W2149185747 cites W1589194933 @default.
- W2149185747 cites W1592701464 @default.
- W2149185747 cites W1780183312 @default.
- W2149185747 cites W1816761971 @default.
- W2149185747 cites W1970910346 @default.
- W2149185747 cites W1971056717 @default.
- W2149185747 cites W1978469902 @default.
- W2149185747 cites W1982337820 @default.
- W2149185747 cites W1990213899 @default.
- W2149185747 cites W1991975522 @default.
- W2149185747 cites W199729741 @default.
- W2149185747 cites W2002782759 @default.
- W2149185747 cites W2004664607 @default.
- W2149185747 cites W2005269323 @default.
- W2149185747 cites W2009886857 @default.
- W2149185747 cites W2011030679 @default.
- W2149185747 cites W2015495840 @default.
- W2149185747 cites W2015524565 @default.
- W2149185747 cites W2029852810 @default.
- W2149185747 cites W2030118761 @default.
- W2149185747 cites W2031813404 @default.
- W2149185747 cites W2033753214 @default.
- W2149185747 cites W2038479043 @default.
- W2149185747 cites W2047398915 @default.
- W2149185747 cites W2052753191 @default.
- W2149185747 cites W2063486944 @default.
- W2149185747 cites W2076088666 @default.
- W2149185747 cites W2082890245 @default.
- W2149185747 cites W2083632015 @default.
- W2149185747 cites W2085479011 @default.
- W2149185747 cites W2086624123 @default.
- W2149185747 cites W2088255007 @default.
- W2149185747 cites W2088438660 @default.
- W2149185747 cites W2098672716 @default.
- W2149185747 cites W2102085111 @default.
- W2149185747 cites W2104485296 @default.
- W2149185747 cites W2111759041 @default.
- W2149185747 cites W2112343158 @default.
- W2149185747 cites W2131666890 @default.
- W2149185747 cites W2133391628 @default.
- W2149185747 cites W2151955120 @default.
- W2149185747 cites W2156199098 @default.
- W2149185747 cites W2156568059 @default.
- W2149185747 cites W2158800860 @default.
- W2149185747 cites W2303212700 @default.
- W2149185747 cites W2337839049 @default.
- W2149185747 cites W2396764557 @default.
- W2149185747 cites W27196345 @default.
- W2149185747 doi "https://doi.org/10.1093/emboj/21.9.2159" @default.
- W2149185747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/125991" @default.
- W2149185747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11980713" @default.
- W2149185747 hasPublicationYear "2002" @default.
- W2149185747 type Work @default.
- W2149185747 sameAs 2149185747 @default.
- W2149185747 citedByCount "45" @default.
- W2149185747 countsByYear W21491857472013 @default.
- W2149185747 countsByYear W21491857472014 @default.
- W2149185747 countsByYear W21491857472015 @default.
- W2149185747 countsByYear W21491857472019 @default.
- W2149185747 countsByYear W21491857472021 @default.
- W2149185747 countsByYear W21491857472022 @default.
- W2149185747 crossrefType "journal-article" @default.
- W2149185747 hasAuthorship W2149185747A5005224886 @default.
- W2149185747 hasAuthorship W2149185747A5008851883 @default.
- W2149185747 hasAuthorship W2149185747A5020985624 @default.
- W2149185747 hasAuthorship W2149185747A5027179598 @default.
- W2149185747 hasAuthorship W2149185747A5032330582 @default.
- W2149185747 hasAuthorship W2149185747A5059611399 @default.
- W2149185747 hasAuthorship W2149185747A5059930066 @default.
- W2149185747 hasAuthorship W2149185747A5063440051 @default.
- W2149185747 hasAuthorship W2149185747A5066150656 @default.
- W2149185747 hasAuthorship W2149185747A5068336316 @default.
- W2149185747 hasAuthorship W2149185747A5077797768 @default.
- W2149185747 hasAuthorship W2149185747A5083290776 @default.
- W2149185747 hasBestOaLocation W21491857472 @default.
- W2149185747 hasConcept C101544691 @default.
- W2149185747 hasConcept C104317684 @default.