Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149189904> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2149189904 endingPage "E277" @default.
- W2149189904 startingPage "E272" @default.
- W2149189904 abstract "Lithium has been shown to increase glucose uptake in skeletal muscle and adipose tissues. The therapeutic effect of lithium on bipolar disease is thought to be mediated by its inhibitory effect on myo-inositol-1-monophosphatase (IMPase). We tested the hypothesis that the stimulatory effect of lithium on glucose uptake results from inhibition of IMPase and the resultant accumulation of inositol monophosphates (IP1) by comparing the effects of lithium and a selective IMPase inhibitor, L-690,488, on isolated rat adipocytes. Insulin produced a concentration-dependent stimulation of 2-deoxy-D-[14C]glucose (2-DG) transport (10 microU/ml caused half-maximal activation). Acute exposure to lithium stimulated basal glucose transport activity in a concentration-dependent manner, with a threefold stimulation at 30 mM lithium. Lithium also potentiated insulin-stimulated 2-DG transport. Lithium produced a concomitant increase in IP1 accumulation. In contrast, L-690,488 increased IP1 to levels comparable to those of lithium without stimulatory effects on 2-DG transport. These results demonstrate that stimulatory effects of lithium on glucose transport are not mediated by the inhibition of IMPase and subsequent accumulation of IP1 in rat adipocytes." @default.
- W2149189904 created "2016-06-24" @default.
- W2149189904 creator A5031816397 @default.
- W2149189904 creator A5042785839 @default.
- W2149189904 creator A5064790476 @default.
- W2149189904 date "1998-08-01" @default.
- W2149189904 modified "2023-10-17" @default.
- W2149189904 title "Stimulatory effect of lithium on glucose transport in rat adipocytes is not mediated by elevation of IP1" @default.
- W2149189904 cites W1536070820 @default.
- W2149189904 cites W1572145162 @default.
- W2149189904 cites W1575373280 @default.
- W2149189904 cites W1586488610 @default.
- W2149189904 cites W1889236699 @default.
- W2149189904 cites W1982943052 @default.
- W2149189904 cites W2005932824 @default.
- W2149189904 cites W2008076717 @default.
- W2149189904 cites W2019659823 @default.
- W2149189904 cites W2050083058 @default.
- W2149189904 cites W2051788298 @default.
- W2149189904 cites W2056272943 @default.
- W2149189904 cites W2057231488 @default.
- W2149189904 cites W2085968319 @default.
- W2149189904 cites W2086906852 @default.
- W2149189904 cites W2114309033 @default.
- W2149189904 cites W2123653154 @default.
- W2149189904 cites W2126704174 @default.
- W2149189904 cites W2133733742 @default.
- W2149189904 cites W2143873575 @default.
- W2149189904 cites W2300552860 @default.
- W2149189904 cites W37575221 @default.
- W2149189904 doi "https://doi.org/10.1152/ajpendo.1998.275.2.e272" @default.
- W2149189904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9688629" @default.
- W2149189904 hasPublicationYear "1998" @default.
- W2149189904 type Work @default.
- W2149189904 sameAs 2149189904 @default.
- W2149189904 citedByCount "16" @default.
- W2149189904 countsByYear W21491899042013 @default.
- W2149189904 countsByYear W21491899042014 @default.
- W2149189904 countsByYear W21491899042017 @default.
- W2149189904 countsByYear W21491899042019 @default.
- W2149189904 countsByYear W21491899042020 @default.
- W2149189904 crossrefType "journal-article" @default.
- W2149189904 hasAuthorship W2149189904A5031816397 @default.
- W2149189904 hasAuthorship W2149189904A5042785839 @default.
- W2149189904 hasAuthorship W2149189904A5064790476 @default.
- W2149189904 hasConcept C126322002 @default.
- W2149189904 hasConcept C134018914 @default.
- W2149189904 hasConcept C161573976 @default.
- W2149189904 hasConcept C171089720 @default.
- W2149189904 hasConcept C185592680 @default.
- W2149189904 hasConcept C24998067 @default.
- W2149189904 hasConcept C2777866211 @default.
- W2149189904 hasConcept C2778024521 @default.
- W2149189904 hasConcept C2778541603 @default.
- W2149189904 hasConcept C2779306644 @default.
- W2149189904 hasConcept C71924100 @default.
- W2149189904 hasConcept C86803240 @default.
- W2149189904 hasConceptScore W2149189904C126322002 @default.
- W2149189904 hasConceptScore W2149189904C134018914 @default.
- W2149189904 hasConceptScore W2149189904C161573976 @default.
- W2149189904 hasConceptScore W2149189904C171089720 @default.
- W2149189904 hasConceptScore W2149189904C185592680 @default.
- W2149189904 hasConceptScore W2149189904C24998067 @default.
- W2149189904 hasConceptScore W2149189904C2777866211 @default.
- W2149189904 hasConceptScore W2149189904C2778024521 @default.
- W2149189904 hasConceptScore W2149189904C2778541603 @default.
- W2149189904 hasConceptScore W2149189904C2779306644 @default.
- W2149189904 hasConceptScore W2149189904C71924100 @default.
- W2149189904 hasConceptScore W2149189904C86803240 @default.
- W2149189904 hasIssue "2" @default.
- W2149189904 hasLocation W21491899041 @default.
- W2149189904 hasLocation W21491899042 @default.
- W2149189904 hasOpenAccess W2149189904 @default.
- W2149189904 hasPrimaryLocation W21491899041 @default.
- W2149189904 hasRelatedWork W1969894012 @default.
- W2149189904 hasRelatedWork W1973482108 @default.
- W2149189904 hasRelatedWork W1995837619 @default.
- W2149189904 hasRelatedWork W2031097196 @default.
- W2149189904 hasRelatedWork W2048870206 @default.
- W2149189904 hasRelatedWork W2054894282 @default.
- W2149189904 hasRelatedWork W2066345847 @default.
- W2149189904 hasRelatedWork W2155793985 @default.
- W2149189904 hasRelatedWork W2158888587 @default.
- W2149189904 hasRelatedWork W2223043162 @default.
- W2149189904 hasVolume "275" @default.
- W2149189904 isParatext "false" @default.
- W2149189904 isRetracted "false" @default.
- W2149189904 magId "2149189904" @default.
- W2149189904 workType "article" @default.