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- W2149194212 abstract "In control anaesthetized baboons subjected to 30 min occlusion of the left anterior descending coronary artery, followed by 5.5 h reperfusion, total plasma levels for creatine kinase (CK) and lactate dehydrogenase (LDH) were markedly elevated in a time‐related manner. In a second group of baboons pretreated 10 min prior to ischaemia with ranolazine [(±)‐N‐(2,6‐dimethyl‐phenyl)‐4[2‐hydroxy‐3‐(2‐methoxyphenoxy)propyl]‐1‐piperazine acetamide dihydrochloride; RS‐43285–193] at 500 μg kg −1 i.v., followed by continuous infusion of 50 μg kg −1 min −1 , neither enzyme was significantly elevated at any time point. Similarly, serum levels of the cardiospecific isoenzyme CK 2 were 8 fold greater in the controls than in the ranolazine‐treated animals at 6 h. The results indicate that ranolazine pretreatment abolished cardiac enzyme release over a 5.5 h reperfusion period, indicating a potential protective effect." @default.
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- W2149194212 date "1990-01-01" @default.
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- W2149194212 title "Prevention of myocardial enzyme release by ranolazine in a primate model of ischaemia with reperfusion" @default.
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- W2149194212 doi "https://doi.org/10.1111/j.1476-5381.1990.tb14641.x" @default.
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