Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149194299> ?p ?o ?g. }
- W2149194299 endingPage "457" @default.
- W2149194299 startingPage "452" @default.
- W2149194299 abstract "Cell cycle progression is monitored by surveillance mechanisms, or cell cycle checkpoints, that ensure that initiation of a later event is coupled with the completion of an early cell cycle event. Deregulated proliferation is a characteristic feature of tumor cells. Moreover, defects in many of the molecules that regulate the cell cycle have been implicated in cancer formation and progression. Key among these are p53, the retinoblastoma protein (pRb) and its related proteins, p107 and pRb2/p130, and cdk inhibitors (p15, p16, p18, p19, p21, p27), all of which act to keep the cell cycle from progressing until all repairs to damaged DNA have been completed. The pRb (pRb/p16(INK4a)/cyclin D1) and p53 (p14(ARF)/mdm2/p53) pathways are the two main cell-cycle control pathways frequently targeted in tumorigenesis, and the alterations occurring in each pathway depend on the tumor type. Virtually all human tumors deregulate either the pRb or p53 pathway, and oftentimes both pathways simultaneously. This review focuses on the genetic and epigenetic alterations affecting the components of mechanisms regulating the progression of the cell cycle and leading to cancer formation and progression." @default.
- W2149194299 created "2016-06-24" @default.
- W2149194299 creator A5024798356 @default.
- W2149194299 creator A5043358600 @default.
- W2149194299 creator A5058965359 @default.
- W2149194299 creator A5084895786 @default.
- W2149194299 date "2005-10-01" @default.
- W2149194299 modified "2023-10-09" @default.
- W2149194299 title "Modulation of Cell Cycle Components by Epigenetic and Genetic Events" @default.
- W2149194299 cites W1504303645 @default.
- W2149194299 cites W1514248240 @default.
- W2149194299 cites W152974073 @default.
- W2149194299 cites W1804201762 @default.
- W2149194299 cites W1966663496 @default.
- W2149194299 cites W1970221755 @default.
- W2149194299 cites W1978672439 @default.
- W2149194299 cites W1980961600 @default.
- W2149194299 cites W1981638868 @default.
- W2149194299 cites W1983269088 @default.
- W2149194299 cites W1983348452 @default.
- W2149194299 cites W1983751803 @default.
- W2149194299 cites W1985626007 @default.
- W2149194299 cites W1986018730 @default.
- W2149194299 cites W1989903496 @default.
- W2149194299 cites W1990750564 @default.
- W2149194299 cites W1992708996 @default.
- W2149194299 cites W1994866501 @default.
- W2149194299 cites W1999374180 @default.
- W2149194299 cites W1999491381 @default.
- W2149194299 cites W2002781770 @default.
- W2149194299 cites W2004957378 @default.
- W2149194299 cites W2005131800 @default.
- W2149194299 cites W2008655916 @default.
- W2149194299 cites W2008696287 @default.
- W2149194299 cites W2016617960 @default.
- W2149194299 cites W2018116689 @default.
- W2149194299 cites W2019025111 @default.
- W2149194299 cites W2020330574 @default.
- W2149194299 cites W2020682101 @default.
- W2149194299 cites W2021669819 @default.
- W2149194299 cites W2026968102 @default.
- W2149194299 cites W2027482159 @default.
- W2149194299 cites W2032062839 @default.
- W2149194299 cites W2032953029 @default.
- W2149194299 cites W2050523151 @default.
- W2149194299 cites W2051177925 @default.
- W2149194299 cites W2055077352 @default.
- W2149194299 cites W2055103019 @default.
- W2149194299 cites W2055595737 @default.
- W2149194299 cites W2057769740 @default.
- W2149194299 cites W2058886425 @default.
- W2149194299 cites W2060438880 @default.
- W2149194299 cites W2065308394 @default.
- W2149194299 cites W2066848701 @default.
- W2149194299 cites W2067795112 @default.
- W2149194299 cites W2068160835 @default.
- W2149194299 cites W2069294039 @default.
- W2149194299 cites W2070437985 @default.
- W2149194299 cites W2074932072 @default.
- W2149194299 cites W2080677621 @default.
- W2149194299 cites W2081570461 @default.
- W2149194299 cites W2084891010 @default.
- W2149194299 cites W2091234906 @default.
- W2149194299 cites W2094050085 @default.
- W2149194299 cites W2098953839 @default.
- W2149194299 cites W2100894466 @default.
- W2149194299 cites W2103892640 @default.
- W2149194299 cites W2108685474 @default.
- W2149194299 cites W2115573876 @default.
- W2149194299 cites W2116583492 @default.
- W2149194299 cites W2120001940 @default.
- W2149194299 cites W2120723709 @default.
- W2149194299 cites W2121038486 @default.
- W2149194299 cites W2121228733 @default.
- W2149194299 cites W2122889044 @default.
- W2149194299 cites W2124870706 @default.
- W2149194299 cites W2128694990 @default.
- W2149194299 cites W2142432694 @default.
- W2149194299 cites W2145348333 @default.
- W2149194299 cites W2155673360 @default.
- W2149194299 cites W2156299289 @default.
- W2149194299 cites W2157062944 @default.
- W2149194299 cites W2315011230 @default.
- W2149194299 cites W2472810578 @default.
- W2149194299 cites W2791873134 @default.
- W2149194299 cites W53715958 @default.
- W2149194299 doi "https://doi.org/10.1053/j.seminoncol.2005.07.009" @default.
- W2149194299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16210085" @default.
- W2149194299 hasPublicationYear "2005" @default.
- W2149194299 type Work @default.
- W2149194299 sameAs 2149194299 @default.
- W2149194299 citedByCount "73" @default.
- W2149194299 countsByYear W21491942992012 @default.
- W2149194299 countsByYear W21491942992013 @default.
- W2149194299 countsByYear W21491942992014 @default.
- W2149194299 countsByYear W21491942992016 @default.
- W2149194299 countsByYear W21491942992017 @default.
- W2149194299 countsByYear W21491942992020 @default.