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- W2149197864 abstract "In this study we evaluated 38 TM patients (recruited from theThalassemia centre of Palermo), 14 male and 24 female. Weobtained the BMD of the lumbar spine (L1 L4), femoral neck(DEXA; Lunar DPX plus), serum levels of PTH, osteocalcin, Ctelopeptideand bone alkaline phosphatase.Patients with TM presented low bone mass at lumbar spine (Zscore: L1-L4 -2.23 ± 1.25 SD), and femoral neck (Z-score -1.52 ±1.14 SD): 50% of subjects were osteoporotic; 36% osteopenicsand 13.1% were normal. Were presented normal serum levels ofosteocalcin (19.1 ± 8 ng/ml), but hight level of bone alkaline phosphatase(24.2 ± 9.1 g/L), and C-telopeptide (4528 ± 2821 pmol/L).Patients with TM presented BMD reduction more marked atlumbar spine than femur; increased C telopeptides and alkalinephosphatase were observed, although osteocalcin wasnormal. Patients with TM presented low bone mineral densityand high bone turnover. It’s possible that subjects with increasedreabsorbtion, have a marked bone loss and a progressiveincreased fracture risk." @default.
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- W2149197864 date "2005-01-01" @default.
- W2149197864 modified "2023-09-26" @default.
- W2149197864 title "Low bone mineral density and high bone turnover in adult subjects with thalassemia major" @default.
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