Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149201295> ?p ?o ?g. }
- W2149201295 endingPage "3375" @default.
- W2149201295 startingPage "3368" @default.
- W2149201295 abstract "GnIH was first identified in avian species, and there is now strong evidence that it is operant in mammals as an inhibitor of reproduction. Mammalian gonadotropin-inhibitory hormone (GnIH)-3 is encoded by the RFRP gene in neurons of the dorsomedial nucleus. These neurons project to the median eminence, predicting a role as a secreted neurohormone and regulation of the pituitary gonadotropes. To determine whether GnIH-3 is a secreted neurohormone, we measured its concentration in hypophyseal portal blood in ewes during the nonbreeding (anestrous) season and during the luteal and follicular phases of the estrous cycle in the breeding season. Paired portal and jugular blood samples were collected and plasma prepared for RIA using an ovine GnIH-3 antibody. Pulsatile GnIH-3 secretion was observed in the portal blood of all animals. Mean GnIH-3 pulse amplitude and pulse frequency was higher during the nonbreeding season. GnIH-3 was virtually undetectable in peripheral blood plasma. There was a lack of association between secretory pulses of GnIH-3 (portal) and LH (peripheral). To determine the role of secreted GnIH-3, we examined its effects on GnRH-stimulated LH secretion in hypothalamo-pituitary-disconnected ewes; a significant reduction in the LH response to GnRH was observed. Finally, to identify cellular targets in the pituitary, the expression of GnIH receptor [G protein-coupled receptor 147 (GPR147)] in fractions enriched for gonadotropes somatotropes, and lactotropes was examined; expression was observed in each cell type. These data show GnIH-3 is secreted into portal blood to act on pituitary gonadotropes, reducing the action of GnRH." @default.
- W2149201295 created "2016-06-24" @default.
- W2149201295 creator A5003698342 @default.
- W2149201295 creator A5026710489 @default.
- W2149201295 creator A5061901592 @default.
- W2149201295 creator A5067502603 @default.
- W2149201295 date "2012-05-01" @default.
- W2149201295 modified "2023-09-27" @default.
- W2149201295 title "Gonadotropin-Inhibitory Hormone (GnIH) Secretion into the Ovine Hypophyseal Portal System" @default.
- W2149201295 cites W1484971035 @default.
- W2149201295 cites W1508466752 @default.
- W2149201295 cites W1540547666 @default.
- W2149201295 cites W1693928862 @default.
- W2149201295 cites W1966997611 @default.
- W2149201295 cites W197226915 @default.
- W2149201295 cites W1976159865 @default.
- W2149201295 cites W1996613370 @default.
- W2149201295 cites W1997484674 @default.
- W2149201295 cites W2004119056 @default.
- W2149201295 cites W2009424714 @default.
- W2149201295 cites W2010217927 @default.
- W2149201295 cites W2010307497 @default.
- W2149201295 cites W2012822367 @default.
- W2149201295 cites W2014318642 @default.
- W2149201295 cites W2017325384 @default.
- W2149201295 cites W2019501332 @default.
- W2149201295 cites W2024644536 @default.
- W2149201295 cites W2024749335 @default.
- W2149201295 cites W2033011212 @default.
- W2149201295 cites W2038039689 @default.
- W2149201295 cites W2055463774 @default.
- W2149201295 cites W2055660125 @default.
- W2149201295 cites W2058563831 @default.
- W2149201295 cites W2066166647 @default.
- W2149201295 cites W2075442956 @default.
- W2149201295 cites W2077412978 @default.
- W2149201295 cites W2081134805 @default.
- W2149201295 cites W2083323779 @default.
- W2149201295 cites W2085109901 @default.
- W2149201295 cites W2095552730 @default.
- W2149201295 cites W2098917312 @default.
- W2149201295 cites W2100733933 @default.
- W2149201295 cites W2103753396 @default.
- W2149201295 cites W2115381325 @default.
- W2149201295 cites W2116806096 @default.
- W2149201295 cites W2116934373 @default.
- W2149201295 cites W2119788961 @default.
- W2149201295 cites W2123152448 @default.
- W2149201295 cites W2127199761 @default.
- W2149201295 cites W2166025044 @default.
- W2149201295 doi "https://doi.org/10.1210/en.2012-1088" @default.
- W2149201295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3380300" @default.
- W2149201295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22549225" @default.
- W2149201295 hasPublicationYear "2012" @default.
- W2149201295 type Work @default.
- W2149201295 sameAs 2149201295 @default.
- W2149201295 citedByCount "86" @default.
- W2149201295 countsByYear W21492012952012 @default.
- W2149201295 countsByYear W21492012952013 @default.
- W2149201295 countsByYear W21492012952014 @default.
- W2149201295 countsByYear W21492012952015 @default.
- W2149201295 countsByYear W21492012952016 @default.
- W2149201295 countsByYear W21492012952017 @default.
- W2149201295 countsByYear W21492012952018 @default.
- W2149201295 countsByYear W21492012952019 @default.
- W2149201295 countsByYear W21492012952020 @default.
- W2149201295 countsByYear W21492012952021 @default.
- W2149201295 countsByYear W21492012952022 @default.
- W2149201295 countsByYear W21492012952023 @default.
- W2149201295 crossrefType "journal-article" @default.
- W2149201295 hasAuthorship W2149201295A5003698342 @default.
- W2149201295 hasAuthorship W2149201295A5026710489 @default.
- W2149201295 hasAuthorship W2149201295A5061901592 @default.
- W2149201295 hasAuthorship W2149201295A5067502603 @default.
- W2149201295 hasBestOaLocation W21492012951 @default.
- W2149201295 hasConcept C126322002 @default.
- W2149201295 hasConcept C134018914 @default.
- W2149201295 hasConcept C197012351 @default.
- W2149201295 hasConcept C2777003273 @default.
- W2149201295 hasConcept C2777658017 @default.
- W2149201295 hasConcept C2778575703 @default.
- W2149201295 hasConcept C2778782382 @default.
- W2149201295 hasConcept C2778894405 @default.
- W2149201295 hasConcept C2779029589 @default.
- W2149201295 hasConcept C2779067335 @default.
- W2149201295 hasConcept C71315377 @default.
- W2149201295 hasConcept C71924100 @default.
- W2149201295 hasConcept C86803240 @default.
- W2149201295 hasConcept C94984642 @default.
- W2149201295 hasConceptScore W2149201295C126322002 @default.
- W2149201295 hasConceptScore W2149201295C134018914 @default.
- W2149201295 hasConceptScore W2149201295C197012351 @default.
- W2149201295 hasConceptScore W2149201295C2777003273 @default.
- W2149201295 hasConceptScore W2149201295C2777658017 @default.
- W2149201295 hasConceptScore W2149201295C2778575703 @default.
- W2149201295 hasConceptScore W2149201295C2778782382 @default.
- W2149201295 hasConceptScore W2149201295C2778894405 @default.
- W2149201295 hasConceptScore W2149201295C2779029589 @default.