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- W2149202384 abstract "We describe the interplay between three sensory protein kinases in yeast: AMP-regulated kinase (AMPK, or SNF1 in yeast), PAS kinase 1 (Psk1 in yeast), and the target of rapamycin complex 1 (TORC1). This signaling cascade occurs through the SNF1-dependent phosphorylation and activation of Psk1, which phosphorylates and activates poly(A)- binding protein binding protein 1 (Pbp1), which then inhibits TORC1 through sequestration at stress granules. The SNF1-dependent phosphorylation of Psk1 appears to be direct, in that Snf1 is necessary and sufficient for Psk1 activation by alternate carbon sources, is required for altered Psk1 protein mobility, is able to phosphorylate Psk1 in vitro, and binds Psk1 via its substrate-targeting subunit Gal83. Evidence for the direct phosphorylation and activation of Pbp1 by Psk1 is also provided by in vitro and in vivo kinase assays, including the reduction of Pbp1 localization at distinct cytoplasmic foci and subsequent rescue of TORC1 inhibition in PAS kinase-deficient yeast. In support of this signaling cascade, Snf1-deficient cells display increased TORC1 activity, whereas cells containing hyperactive Snf1 display a PAS kinase-dependent decrease in TORC1 activity. This interplay between yeast SNF1, Psk1, and TORC1 allows for proper glucose allocation during nutrient depletion, reducing cell growth and proliferation when energy is low." @default.
- W2149202384 created "2016-06-24" @default.
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- W2149202384 creator A5043846151 @default.
- W2149202384 creator A5050383254 @default.
- W2149202384 creator A5070967005 @default.
- W2149202384 date "2015-02-01" @default.
- W2149202384 modified "2023-10-13" @default.
- W2149202384 title "PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1" @default.
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- W2149202384 doi "https://doi.org/10.1091/mbc.e14-06-1088" @default.
- W2149202384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4310746" @default.
- W2149202384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25428989" @default.
- W2149202384 hasPublicationYear "2015" @default.
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