FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149204225> ?p ?o ?g. }

• W2149204225 endingPage "e85396" @default.
• W2149204225 startingPage "e85396" @default.
• W2149204225 abstract "Cell-released microvesicles (MVs) represent a novel way of cell-to-cell communication. Previous evidence indicates that endothelial progenitor cells (EPCs)-derived MVs can modulate endothelial cell survival and proliferation. In this study, we evaluated whether EPC-MVs protect cardiomyocytes (CMs) against angiotensin II (Ang II)-induced hypertrophy and apoptosis. The H9c2 CMs were exposed to Ang II in the presence or absence of EPC-MVs. Cell viability, apoptosis, surface area and β-myosin heavy chain (β-MHC) expression were analyzed. Meanwhile, reactive oxygen species (ROS), serine/threonine kinase (Akt), endothelial nitric oxide synthase (eNOS), and their phosphorylated proteins (p-Akt, p-eNOS) were measured. Phosphatidylinositol-3-kinase (PI3K) and NOS inhibitors were used for pathway verification. The role of MV-carried RNAs in mediating these effects was also explored. Results showed 1) EPC-MVs were able to protect CMs against Ang II-induced changes in cell viability, apoptosis, surface area, β-MHC expression and ROS over-production; 2) The effects were accompanied with the up-regulation of Akt/p-Akt and its downstream eNOS/p-eNOS, and were abolished by PI3K inhibition or partially blocked by NOS inhibition; 3) Depletion of RNAs from EPC-MVs partially or totally eliminated the effects of EPC-MVs. Our data indicate that EPC-MVs protect CMs from hypertrophy and apoptosis through activating the PI3K/Akt/eNOS pathway via the RNAs carried by EPC-MVs." @default.
• W2149204225 created "2016-06-24" @default.
• W2149204225 creator A5012808550 @default.
• W2149204225 creator A5018433390 @default.
• W2149204225 creator A5022814757 @default.
• W2149204225 creator A5036882566 @default.
• W2149204225 creator A5067508686 @default.
• W2149204225 creator A5076699095 @default.
• W2149204225 creator A5078052268 @default.
• W2149204225 creator A5081052339 @default.
• W2149204225 date "2014-01-02" @default.
• W2149204225 modified "2023-10-13" @default.
• W2149204225 title "EPC-Derived Microvesicles Protect Cardiomyocytes from Ang II-Induced Hypertrophy and Apoptosis" @default.
• W2149204225 cites W1484950470 @default.
• W2149204225 cites W1964071694 @default.
• W2149204225 cites W1969108844 @default.
• W2149204225 cites W1972879419 @default.
• W2149204225 cites W1980775727 @default.
• W2149204225 cites W1983820802 @default.
• W2149204225 cites W1985236576 @default.
• W2149204225 cites W2003027995 @default.
• W2149204225 cites W2017683119 @default.
• W2149204225 cites W2021458745 @default.
• W2149204225 cites W2021861291 @default.
• W2149204225 cites W2023568868 @default.
• W2149204225 cites W2026301127 @default.
• W2149204225 cites W2041550708 @default.
• W2149204225 cites W2046230753 @default.
• W2149204225 cites W2046949827 @default.
• W2149204225 cites W2047288034 @default.
• W2149204225 cites W2053704719 @default.
• W2149204225 cites W2062139849 @default.
• W2149204225 cites W2071881835 @default.
• W2149204225 cites W2074723035 @default.
• W2149204225 cites W2090049175 @default.
• W2149204225 cites W2093200537 @default.
• W2149204225 cites W2101957836 @default.
• W2149204225 cites W2102453345 @default.
• W2149204225 cites W2108319213 @default.
• W2149204225 cites W2109893157 @default.
• W2149204225 cites W2112333460 @default.
• W2149204225 cites W2112746619 @default.
• W2149204225 cites W2119376007 @default.
• W2149204225 cites W2121882633 @default.
• W2149204225 cites W2125454893 @default.
• W2149204225 cites W2128638548 @default.
• W2149204225 cites W2148293251 @default.
• W2149204225 cites W2156887090 @default.
• W2149204225 cites W2171345666 @default.
• W2149204225 cites W2314648452 @default.
• W2149204225 cites W2334499091 @default.
• W2149204225 doi "https://doi.org/10.1371/journal.pone.0085396" @default.
• W2149204225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3879348" @default.
• W2149204225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24392165" @default.
• W2149204225 hasPublicationYear "2014" @default.
• W2149204225 type Work @default.
• W2149204225 sameAs 2149204225 @default.
• W2149204225 citedByCount "62" @default.
• W2149204225 countsByYear W21492042252014 @default.
• W2149204225 countsByYear W21492042252015 @default.
• W2149204225 countsByYear W21492042252016 @default.
• W2149204225 countsByYear W21492042252017 @default.
• W2149204225 countsByYear W21492042252018 @default.
• W2149204225 countsByYear W21492042252019 @default.
• W2149204225 countsByYear W21492042252020 @default.
• W2149204225 countsByYear W21492042252021 @default.
• W2149204225 countsByYear W21492042252022 @default.
• W2149204225 countsByYear W21492042252023 @default.
• W2149204225 crossrefType "journal-article" @default.
• W2149204225 hasAuthorship W2149204225A5012808550 @default.
• W2149204225 hasAuthorship W2149204225A5018433390 @default.
• W2149204225 hasAuthorship W2149204225A5022814757 @default.
• W2149204225 hasAuthorship W2149204225A5036882566 @default.
• W2149204225 hasAuthorship W2149204225A5067508686 @default.
• W2149204225 hasAuthorship W2149204225A5076699095 @default.
• W2149204225 hasAuthorship W2149204225A5078052268 @default.
• W2149204225 hasAuthorship W2149204225A5081052339 @default.
• W2149204225 hasBestOaLocation W21492042251 @default.
• W2149204225 hasConcept C104317684 @default.
• W2149204225 hasConcept C145059251 @default.
• W2149204225 hasConcept C178790620 @default.
• W2149204225 hasConcept C185592680 @default.
• W2149204225 hasConcept C190283241 @default.
• W2149204225 hasConcept C201750760 @default.
• W2149204225 hasConcept C20518536 @default.
• W2149204225 hasConcept C2777622882 @default.
• W2149204225 hasConcept C2778326061 @default.
• W2149204225 hasConcept C2780152582 @default.
• W2149204225 hasConcept C28328180 @default.
• W2149204225 hasConcept C519581460 @default.
• W2149204225 hasConcept C53227056 @default.
• W2149204225 hasConcept C55493867 @default.
• W2149204225 hasConcept C62478195 @default.
• W2149204225 hasConcept C75217442 @default.
• W2149204225 hasConcept C86554907 @default.
• W2149204225 hasConcept C86803240 @default.
• W2149204225 hasConcept C95444343 @default.
• W2149204225 hasConceptScore W2149204225C104317684 @default.

• next