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- W2149208170 abstract "The small ubiquitin-like modifier SUMO conjugates transcription factors and suppresses their respective activation of target genes. Although various SUMO-modified transcription factors have been isolated, mechanisms whereby sumoylated-substrates modulate transcription remain unknown. Here, we purified ARIP4 (AR interacting protein 4, a Rad54 family member and a SNF2 chromatin remodeling factor), which interacts with sumoylated Ad4BP/SF-1 through two SUMO-interacting motifs and one Ad4BP/SF-1–binding region. Remarkably, ARIP4 also interacts selectively with other sumoylated nuclear receptors including LRH-1, AR, and GR. Interestingly, the ATPase activity of ARIP4 was stimulated in the presence of sumoylated Ad4BP/SF-1 and the Ad4BP/SF-1–binding site containing double-stranded DNA. ChIP assays and siRNA studies strongly suggested that ARIP4 temporally suppresses Ad4BP/SF-1–mediated transcription through its transient recruitment to target genes. These findings suggest that ARIP4 may be a cofactor that modulates SUMO-mediated fine-tuning of transcriptional suppression." @default.
- W2149208170 created "2016-06-24" @default.
- W2149208170 creator A5076833397 @default.
- W2149208170 creator A5087603402 @default.
- W2149208170 creator A5088209852 @default.
- W2149208170 creator A5089583817 @default.
- W2149208170 date "2009-10-01" @default.
- W2149208170 modified "2023-09-26" @default.
- W2149208170 title "Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated Nuclear Receptor Ad4BP/SF-1" @default.
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- W2149208170 doi "https://doi.org/10.1091/mbc.e08-12-1247" @default.
- W2149208170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2754937" @default.
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