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- W2149209186 abstract "Hereditary Hemorrhagic Telangiectasia-1 (HHT-1) is a vascular disease caused by mutations in the endoglin (Eng)/CD105 gene. The objective of this study was to quantify the oxidative state of a rodent model of HHT-1 using an optical imaging technique. We used a cryofluorescence imaging instrument to quantitatively assess tissue metabolism in this model. Mitochondrial redox ratio (FAD/NADH), FAD RR, was used as a quantitative marker of the metabolic status and was examined in the kidneys, and eyes of wild-type and Eng +/- mice. Kidneys and eyes from wild-type P21, 6W, and 10M old mice showed, respectively, a 9% (±2), 24% (±0.4), 15% (±1), and 23% (±4), 33% (±0.6), and 30% (±2) change in the mean FAD RR compared to Eng +/- mice at the same age. Thus, endoglin haploinsufficiency is associated with less oxidative stress in various organs and mitigation of angiogenesis." @default.
- W2149209186 created "2016-06-24" @default.
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- W2149209186 date "2013-06-06" @default.
- W2149209186 modified "2023-09-27" @default.
- W2149209186 title "Organ specific optical imaging of mitochondrial redox state in a rodent model of hereditary hemorrhagic telangiectasia-1" @default.
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- W2149209186 doi "https://doi.org/10.1002/jbio.201300033" @default.
- W2149209186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4324470" @default.
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