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• W2149220003 abstract "In the present study, we investigated the role of tumor necrosis factor receptor II (TNF-RII) in human T cell activation induced via the T cell receptor (TCR) in an antigen-presenting cell-independent system. Our results confirm that interaction of TNF-alpha with TNF-RII but not TNF-RI is directly costimulatory to TCR-mediated T cell activation, thereby augmenting T cell proliferation, expression of T cell activation markers (CD25, human leukocyte antigen-DR, TNF-RII), and secretion of cytokines such as interferon-gamma and TNF-alpha. In contrast to the well-defined costimulatory molecule CD28, costimulation via TNF-RII showed significant differences in kinetics, requirement for cross-linking, redundancy of intracellular signaling pathways involved, and the capacity to induce interleukin (IL)-2, IL-10, and IL-13 secretion. In addition, cross-linking TNF-RII had the capacity to down-regulate TCR/CD28-induced Ca++ mobilization, IL-2 mRNA expression, and IL-2 and IL-10 secretion. Taken together, our findings demonstrate that TNF-RII plays a unique role among the T cell costimulatory molecules, as TNF-RII ligation can have positive and negative effects on TCR-dependent signaling. TNF-RII cross-linking has an inhibitory effect on early TCR signaling events proximal to induction of Ca++ flux, which ultimately leads to modulation of the T cell cytokine pattern expressed." @default.
• W2149220003 created "2016-06-24" @default.
• W2149220003 creator A5007011751 @default.
• W2149220003 creator A5016476736 @default.
• W2149220003 creator A5019295607 @default.
• W2149220003 date "2003-07-01" @default.
• W2149220003 modified "2023-10-17" @default.
• W2149220003 title "Regulation of TCR-mediated T cell activation by TNF-RII" @default.
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• W2149220003 doi "https://doi.org/10.1189/jlb.0303112" @default.
• W2149220003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12960285" @default.
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