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- W2149221625 abstract "ABSTRACT We describe phylogenetic and functional studies of three septins in the free-living ciliate Tetrahymena thermophila . Both deletion and overproduction of septins led to vacuolization of mitochondria, destabilization of the nuclear envelope, and increased autophagy. All three green fluorescent protein-tagged septins localized to mitochondria. Specific septins localized to the outer mitochondrial membrane, to septa formed during mitochondrial scission, or to the mitochondrion-associated endoplasmic reticulum. The only other septins known to localize to mitochondria are human ARTS and murine M-septin, both alternatively spliced forms of Sep4 (S. Larisch, Cell Cycle 3:1021-1023, 2004; S. Takahashi, R. Inatome, H. Yamamura, and S. Yanagi, Genes Cells 8:81-93, 2003). It therefore appears that septins have been recruited to mitochondrial functions independently in at least two eukaryotic lineages and in both cases are involved in apoptotic events." @default.
- W2149221625 created "2016-06-24" @default.
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- W2149221625 creator A5006343762 @default.
- W2149221625 creator A5021206956 @default.
- W2149221625 creator A5073887433 @default.
- W2149221625 date "2008-08-01" @default.
- W2149221625 modified "2023-09-25" @default.
- W2149221625 title "Septins Stabilize Mitochondria in <i>Tetrahymena thermophila</i>" @default.
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- W2149221625 doi "https://doi.org/10.1128/ec.00085-08" @default.
- W2149221625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2519767" @default.
- W2149221625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18586950" @default.
- W2149221625 hasPublicationYear "2008" @default.
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