Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149222021> ?p ?o ?g. }
- W2149222021 endingPage "e0139720" @default.
- W2149222021 startingPage "e0139720" @default.
- W2149222021 abstract "Objective Recent evidence has suggested that AHNAK expression is altered in obesity, although its role in adipose tissue development remains unclear. The objective of this study was to determine the molecular mechanism by which Ahnak influences adipogenesis and glucose homeostasis. Design We investigated the in vitro role of AHNAK in adipogenesis using adipose-derived mesenchymal stem cells (ADSCs) and C3H10T1/2 cells. AHNAK-KO male mice were fed a high-fat diet (HFD; 60% calories from fat) and examined for glucose and insulin tolerances, for body fat compositions, and by hyperinsulinemic-euglycemic clamping. Energy expenditures were assessed using metabolic cages and by measuring the expression levels of genes involved in thermogenesis in white or brown adipose tissues. Results Adipogenesis in ADSCs was impaired in AHNAK-KO mice. The loss of AHNAK led to decreased BMP4/SMAD1 signaling, resulting in the downregulation of key regulators of adipocyte differentiation (P<0.05). AHNAK directly interacted with SMAD1 on the Pparγ2 promoter. Concomitantly, HFD-fed AHNAK-KO mice displayed reduced hepatosteatosis and improved metabolic profiles, including improved glucose tolerance (P<0.001), enhanced insulin sensitivity (P<0.001), and increased energy expenditure (P<0.05), without undergoing alterations in food intake and physical activity. Conclusion AHNAK plays a crucial role in body fat accumulation by regulating adipose tissue development via interaction with the SMAD1 protein and can be involved in metabolic homeostasis." @default.
- W2149222021 created "2016-06-24" @default.
- W2149222021 creator A5005416246 @default.
- W2149222021 creator A5011925902 @default.
- W2149222021 creator A5022011748 @default.
- W2149222021 creator A5025571797 @default.
- W2149222021 creator A5031528316 @default.
- W2149222021 creator A5033840544 @default.
- W2149222021 creator A5046219540 @default.
- W2149222021 creator A5046318848 @default.
- W2149222021 creator A5052536505 @default.
- W2149222021 creator A5057807816 @default.
- W2149222021 creator A5067518349 @default.
- W2149222021 creator A5067623600 @default.
- W2149222021 creator A5088061801 @default.
- W2149222021 creator A5091818510 @default.
- W2149222021 date "2015-10-14" @default.
- W2149222021 modified "2023-09-26" @default.
- W2149222021 title "Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure" @default.
- W2149222021 cites W1773423156 @default.
- W2149222021 cites W1963631387 @default.
- W2149222021 cites W1966418530 @default.
- W2149222021 cites W1966983998 @default.
- W2149222021 cites W1986222936 @default.
- W2149222021 cites W1991094809 @default.
- W2149222021 cites W1994667169 @default.
- W2149222021 cites W1998696289 @default.
- W2149222021 cites W2003529103 @default.
- W2149222021 cites W2004039221 @default.
- W2149222021 cites W2004130992 @default.
- W2149222021 cites W2004552697 @default.
- W2149222021 cites W2007527212 @default.
- W2149222021 cites W2008497408 @default.
- W2149222021 cites W2016727307 @default.
- W2149222021 cites W2020673299 @default.
- W2149222021 cites W2021301321 @default.
- W2149222021 cites W2026195376 @default.
- W2149222021 cites W2027849612 @default.
- W2149222021 cites W2035296038 @default.
- W2149222021 cites W2036734848 @default.
- W2149222021 cites W2045894877 @default.
- W2149222021 cites W2046129276 @default.
- W2149222021 cites W2048142624 @default.
- W2149222021 cites W2059992589 @default.
- W2149222021 cites W2061837746 @default.
- W2149222021 cites W2084913992 @default.
- W2149222021 cites W2088662406 @default.
- W2149222021 cites W2088986234 @default.
- W2149222021 cites W2089374787 @default.
- W2149222021 cites W2099007621 @default.
- W2149222021 cites W2101912765 @default.
- W2149222021 cites W2103811512 @default.
- W2149222021 cites W2110852820 @default.
- W2149222021 cites W2115971158 @default.
- W2149222021 cites W2119756816 @default.
- W2149222021 cites W2123371309 @default.
- W2149222021 cites W2125510262 @default.
- W2149222021 cites W2125711274 @default.
- W2149222021 cites W2127555681 @default.
- W2149222021 cites W2132169416 @default.
- W2149222021 cites W2132409221 @default.
- W2149222021 cites W2135493585 @default.
- W2149222021 cites W2135667395 @default.
- W2149222021 cites W2139823456 @default.
- W2149222021 cites W2141138727 @default.
- W2149222021 cites W2151022783 @default.
- W2149222021 cites W2152300515 @default.
- W2149222021 cites W2156159359 @default.
- W2149222021 cites W2156865358 @default.
- W2149222021 cites W2159287501 @default.
- W2149222021 cites W2170651583 @default.
- W2149222021 doi "https://doi.org/10.1371/journal.pone.0139720" @default.
- W2149222021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4668090" @default.
- W2149222021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26629899" @default.
- W2149222021 hasPublicationYear "2015" @default.
- W2149222021 type Work @default.
- W2149222021 sameAs 2149222021 @default.
- W2149222021 citedByCount "18" @default.
- W2149222021 countsByYear W21492220212015 @default.
- W2149222021 countsByYear W21492220212016 @default.
- W2149222021 countsByYear W21492220212017 @default.
- W2149222021 countsByYear W21492220212018 @default.
- W2149222021 countsByYear W21492220212019 @default.
- W2149222021 countsByYear W21492220212020 @default.
- W2149222021 countsByYear W21492220212021 @default.
- W2149222021 countsByYear W21492220212022 @default.
- W2149222021 countsByYear W21492220212023 @default.
- W2149222021 crossrefType "journal-article" @default.
- W2149222021 hasAuthorship W2149222021A5005416246 @default.
- W2149222021 hasAuthorship W2149222021A5011925902 @default.
- W2149222021 hasAuthorship W2149222021A5022011748 @default.
- W2149222021 hasAuthorship W2149222021A5025571797 @default.
- W2149222021 hasAuthorship W2149222021A5031528316 @default.
- W2149222021 hasAuthorship W2149222021A5033840544 @default.
- W2149222021 hasAuthorship W2149222021A5046219540 @default.
- W2149222021 hasAuthorship W2149222021A5046318848 @default.
- W2149222021 hasAuthorship W2149222021A5052536505 @default.
- W2149222021 hasAuthorship W2149222021A5057807816 @default.