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• W2149223824 endingPage "477" @default.
• W2149223824 startingPage "466" @default.
• W2149223824 abstract "The ability of basic leucine zipper transcription factors for homo- or heterodimerization provides a paradigm for combinatorial control of eukaryotic gene expression. It has been unclear, however, how facultative dimerization results in alternative DNA-binding repertoires on distinct regulatory elements. To unravel the molecular basis of such coupled preferences, we determined two high-resolution structures of the transcription factor MafB as a homodimer and as a heterodimer with c-Fos bound to variants of the Maf-recognition element. The structures revealed several unexpected and dimer-specific coiled-coil-heptad interactions. Based on these findings, we have engineered two MafB mutants with opposite dimerization preferences. One of them showed a strong preference for MafB/c-Fos heterodimerization and enabled selection of heterodimer-favoring over homodimer-specific Maf-recognition element variants. Our data provide a concept for transcription factor design to selectively activate dimer-specific pathways and binding repertoires." @default.
• W2149223824 created "2016-06-24" @default.
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• W2149223824 date "2014-03-01" @default.
• W2149223824 modified "2023-09-30" @default.
• W2149223824 title "Design of a bZip Transcription Factor with Homo/Heterodimer-Induced DNA-Binding Preference" @default.
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• W2149223824 doi "https://doi.org/10.1016/j.str.2013.12.017" @default.
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