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- W2149226779 abstract "Abstract 1. 1. Circulatory and ventilatory studies before and one hour after the administration of an effective intravenous dose of lanatoside C to six patients with chronic rheumatic heart disease and mitral stenosis were reported. 2. 2. Clinical improvement was noted in only three of the six patients. 3. 3. Lanatoside C consistently increased the work of the heart by increasing the right ventricular and peripheral arterial pressures and (except in one case) the rate of systemic blood flow. The reasons for the lack of an increase in the rate of systemic blood flow in one case were discussed. 4. 4. The increased work of the heart seen after lanatoside C in some patients who had neither frank signs of congestive failure nor a clear-cut clinical response to full digitalization was cited as evidence supporting the early use of digitalis in patients with mitral stenosis. 5. 5. In the presence of multiple valve lesions, a rise in the rate of systemic blood flow after digitalization was suggested as a necessary criterion in the selection of patients for mitral valvulotomy." @default.
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- W2149226779 date "1954-02-01" @default.
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- W2149226779 title "The effect of lanatoside C on the circulatory and ventilatory changes of chronic rheumatic heart disease with mitral stenosis" @default.
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- W2149226779 doi "https://doi.org/10.1016/0002-8703(54)90255-0" @default.
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