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• W2149233622 abstract "Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with community-acquired pneumonia (CAP). We investigated the impact of COPD on outcomes of CAP patients. We prospectively studied the clinical presentation of 1,379 patients admitted with CAP during a 4-yr period. A comparative analysis of disease severity and course was performed between 212 patients with COPD, as confirmed by spirometry, and 1,167 non-COPD patients. COPD patients (mean forced expiratory volume in 1 s 47.7±16.3% predicted) were older and more likely to have previously received antibiotics (37.1% <i>versus</i> 28.3%; p<0.01) than those without COPD. They presented with more severe respiratory failure (arterial oxygen tension<i>/</i>inspiratory oxygen fraction 270.4 <i>versus</i> 287.8; p<0.01) and more severe pneumonia (pneumonia severity index 118.3 <i>versus</i> 108.5; p<0.001) compared with non-COPD patients. However, COPD patients had less multilobar infiltration (44 (21%) <i>versus</i> 349 (30%); p<0.01) and fewer pulmonary complications (24 (14%) <i>versus</i> 241 (24%); p<0.01). A total of 89 (6.5%) patients died within 30 days. COPD patients had no significant difference in their 30-day mortality rate compared with non-COPD patients (nine (4.2%) patients <i>versus</i> 81 (7%); p=0.14). Despite worse clinical presentation, COPD patients had a similar mortality rate compared to non-COPD patients. Previous antibiotic treatment and the decreased incidence of pulmonary complications in COPD may account for these findings." @default.
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• W2149233622 date "2011-09-15" @default.
• W2149233622 modified "2023-10-10" @default.
• W2149233622 title "Severity and outcomes of hospitalised community-acquired pneumonia in COPD patients" @default.
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• W2149233622 doi "https://doi.org/10.1183/09031936.00067111" @default.
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