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- W2149236431 startingPage "55" @default.
- W2149236431 abstract "Hairy cell Leukaemia (HCL) is a rare neoplasm of peripheral B cells which represents a paradox in oncology. Despite its largely unknown origin and behaviour, HCL is one of the few example of dramatic success in the treatment of a malignancy. The recent steps forward to understanding the biology of HCL from immunogenetic and genomic studies have recently provided new insight into diagnosis and prognosis. Several data from immunoglobulin gene (IG) analysis have provided hints regarding the cell of origin and the ongoing selective interactions of the tumour BCR with environmental stimuli. It has also recently emerged that an unmutated status of the HCL IG can be associated with failure to respond to cladribine, genetic abnormalities indicative of poor outcome and aggressive disease. These observations suggest a central role of the tumour B-cell receptor in defining the outcome of HCL and that that IG gene analysis may have biological and prognostic relevance. Hopefully, IG analysis will help tailor treatment strategies for the most aggressive cases. Copyright © 2010 John Wiley & Sons, Ltd." @default.
- W2149236431 created "2016-06-24" @default.
- W2149236431 creator A5078295579 @default.
- W2149236431 date "2010-11-02" @default.
- W2149236431 modified "2023-09-26" @default.
- W2149236431 title "Hairy cell leukaemia: biological and clinical overview from immunogenetic insights" @default.
- W2149236431 cites W1243376384 @default.
- W2149236431 cites W1429374962 @default.
- W2149236431 cites W1486928317 @default.
- W2149236431 cites W1524525339 @default.
- W2149236431 cites W1527161131 @default.
- W2149236431 cites W1534536451 @default.
- W2149236431 cites W1680011378 @default.
- W2149236431 cites W177402048 @default.
- W2149236431 cites W1910475489 @default.
- W2149236431 cites W1966498224 @default.
- W2149236431 cites W1967130546 @default.
- W2149236431 cites W1973817726 @default.
- W2149236431 cites W1977602693 @default.
- W2149236431 cites W1979319210 @default.
- W2149236431 cites W1980625328 @default.
- W2149236431 cites W1980919036 @default.
- W2149236431 cites W1986701067 @default.
- W2149236431 cites W1986984323 @default.
- W2149236431 cites W1987650086 @default.
- W2149236431 cites W1995628336 @default.
- W2149236431 cites W1996880822 @default.
- W2149236431 cites W2001144108 @default.
- W2149236431 cites W2004019800 @default.
- W2149236431 cites W2004759170 @default.
- W2149236431 cites W2008060191 @default.
- W2149236431 cites W2008920400 @default.
- W2149236431 cites W2009501393 @default.
- W2149236431 cites W2012660359 @default.
- W2149236431 cites W2015292502 @default.
- W2149236431 cites W2015310682 @default.
- W2149236431 cites W2017176722 @default.
- W2149236431 cites W2019496505 @default.
- W2149236431 cites W2022250122 @default.
- W2149236431 cites W2023435505 @default.
- W2149236431 cites W2024961933 @default.
- W2149236431 cites W2026141770 @default.
- W2149236431 cites W2026634264 @default.
- W2149236431 cites W2029282683 @default.
- W2149236431 cites W2030221171 @default.
- W2149236431 cites W2031669929 @default.
- W2149236431 cites W2033560950 @default.
- W2149236431 cites W2035380874 @default.
- W2149236431 cites W2035798984 @default.
- W2149236431 cites W2044137454 @default.
- W2149236431 cites W204777728 @default.
- W2149236431 cites W2048959161 @default.
- W2149236431 cites W2049195561 @default.
- W2149236431 cites W2049762173 @default.
- W2149236431 cites W2050293969 @default.
- W2149236431 cites W2053584187 @default.
- W2149236431 cites W2055028152 @default.
- W2149236431 cites W2055347215 @default.
- W2149236431 cites W2056154599 @default.
- W2149236431 cites W2062348697 @default.
- W2149236431 cites W2062581231 @default.
- W2149236431 cites W2063108415 @default.
- W2149236431 cites W2064326398 @default.
- W2149236431 cites W2065118401 @default.
- W2149236431 cites W2066433195 @default.
- W2149236431 cites W2068868786 @default.
- W2149236431 cites W2073622904 @default.
- W2149236431 cites W2076690627 @default.
- W2149236431 cites W2077366276 @default.
- W2149236431 cites W2077449764 @default.
- W2149236431 cites W2078641935 @default.
- W2149236431 cites W2079604277 @default.
- W2149236431 cites W2080210323 @default.
- W2149236431 cites W2080672055 @default.
- W2149236431 cites W2082297815 @default.
- W2149236431 cites W2086703018 @default.
- W2149236431 cites W2088991026 @default.
- W2149236431 cites W2091856490 @default.
- W2149236431 cites W2095259773 @default.
- W2149236431 cites W2096036897 @default.
- W2149236431 cites W2096296408 @default.
- W2149236431 cites W2104235597 @default.
- W2149236431 cites W2104501243 @default.
- W2149236431 cites W2106594221 @default.
- W2149236431 cites W2113475715 @default.
- W2149236431 cites W2114832764 @default.
- W2149236431 cites W2115289723 @default.
- W2149236431 cites W2115543909 @default.
- W2149236431 cites W2116324811 @default.
- W2149236431 cites W2122828730 @default.
- W2149236431 cites W2124920464 @default.
- W2149236431 cites W2128312303 @default.
- W2149236431 cites W2131581287 @default.
- W2149236431 cites W2137157133 @default.
- W2149236431 cites W2139315604 @default.
- W2149236431 cites W2140098325 @default.
- W2149236431 cites W2141278010 @default.
- W2149236431 cites W2142099365 @default.