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- W2149240199 abstract "Vascular pathology, in the form of angiogenesis, is important in the perpetuation of rheumatoid arthritis (RA) and, in the form of endothelial dysfunction, contributes to associated cardiovascular co-morbidity. Emerging evidence suggests that TNFα blockade may modify vascular pathology in RA. Serum concentrations of vascular endothelial growth factor (VEGF), a potent endothelial cell-specific growth factor that is up-regulated by pro-inflammatory cytokines and by hypoxia, are elevated in RA and correlate with disease activity. Serum levels of VEGF at first presentation in RA predict radiographic progression of the disease over the subsequent year. Power Doppler ultrasonography is a sensitive method for demonstrating the presence of blood flow in small vessels and the vascular signal correlates with histopathological quantification of the vascular density of synovial tissue. Recent data indicate that high-frequency ultrasound and power Doppler are sensitive tools for evaluation of disease activity and assessment of response to therapy. Power Doppler imaging may also have the potential to predict those patients most at risk of accelerated joint destruction. However, much work has yet to be done to standardize the use of these imaging technologies." @default.
- W2149240199 created "2016-06-24" @default.
- W2149240199 creator A5005730681 @default.
- W2149240199 date "2005-01-11" @default.
- W2149240199 modified "2023-10-05" @default.
- W2149240199 title "Serum vascular markers and vascular imaging in assessment of rheumatoid arthritis disease activity and response to therapy" @default.
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- W2149240199 doi "https://doi.org/10.1093/rheumatology/keh524" @default.
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- W2149240199 hasPublicationYear "2005" @default.
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