Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149241359> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2149241359 endingPage "1177" @default.
- W2149241359 startingPage "1171" @default.
- W2149241359 abstract "To gain further insight into the defence mechanisms against triclosan in a mutant derived from an Escherichia coli strain carrying the triclosan-resistant target enzyme, FabI(G93V).An E. coli imp4231 FabI(G93V) strain was constructed by replacing intact fabI with a linear DNA cassette, fabI(G93V)-CmR, that contains a single mutation, GGT to GTT, at codon 93 of fabI(G93V) and a chloramphenicol resistance gene (CmR) as a marker for the mutant allele by a Red-mediated recombination system. Using this E. coli imp4231 FabI(G93V) strain, nitrosoguanidine (NTG) mutagenesis was performed to generate E. coli IFNs [imp4231 FabI(G93V) treated with NTG] displaying higher MICs of triclosan than its parent strain. The genes overexpressed in E. coli IFN4 were identified by DNA microarray analysis.An E. coli imp4231 FabI(G93V) strain displays approximately 400-fold increased MICs of triclosan (MIC approximately 8 mg/L) compared with the parent strain (MIC approximately 0.02 mg/L). Furthermore, E. coli IFN4 has the highest MIC of triclosan (MIC approximately 80 mg/L). DNA microarray analysis of E. coli IFN4 shows that many genes involved in the biosynthesis of membrane proteins, including transporters, reductases/dehydrogenases and stress response regulators, were highly expressed in the mutant.These results strongly indicate that E. coli IFN cells might protect themselves from triclosan by activating various defence mechanisms, such as (i) changing efflux activities; (ii) capturing the triclosan; and (iii) increasing the expression of important regulators or metabolic enzymes." @default.
- W2149241359 created "2016-06-24" @default.
- W2149241359 creator A5007435240 @default.
- W2149241359 creator A5026224502 @default.
- W2149241359 creator A5091464419 @default.
- W2149241359 date "2010-04-21" @default.
- W2149241359 modified "2023-09-25" @default.
- W2149241359 title "Signature gene expression profile of triclosan-resistant Escherichia coli" @default.
- W2149241359 cites W1482770146 @default.
- W2149241359 cites W1656528362 @default.
- W2149241359 cites W1669810599 @default.
- W2149241359 cites W1937163697 @default.
- W2149241359 cites W1978006078 @default.
- W2149241359 cites W1979973356 @default.
- W2149241359 cites W2000715286 @default.
- W2149241359 cites W2004917621 @default.
- W2149241359 cites W2012185637 @default.
- W2149241359 cites W2034840474 @default.
- W2149241359 cites W2040061014 @default.
- W2149241359 cites W2098078529 @default.
- W2149241359 cites W2108871577 @default.
- W2149241359 cites W2110199291 @default.
- W2149241359 cites W2110684720 @default.
- W2149241359 cites W2116137883 @default.
- W2149241359 cites W2117040346 @default.
- W2149241359 cites W2135769011 @default.
- W2149241359 cites W2149075105 @default.
- W2149241359 cites W2171243523 @default.
- W2149241359 cites W2895207977 @default.
- W2149241359 cites W4240343789 @default.
- W2149241359 doi "https://doi.org/10.1093/jac/dkq114" @default.
- W2149241359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20410062" @default.
- W2149241359 hasPublicationYear "2010" @default.
- W2149241359 type Work @default.
- W2149241359 sameAs 2149241359 @default.
- W2149241359 citedByCount "37" @default.
- W2149241359 countsByYear W21492413592012 @default.
- W2149241359 countsByYear W21492413592013 @default.
- W2149241359 countsByYear W21492413592014 @default.
- W2149241359 countsByYear W21492413592015 @default.
- W2149241359 countsByYear W21492413592016 @default.
- W2149241359 countsByYear W21492413592017 @default.
- W2149241359 countsByYear W21492413592018 @default.
- W2149241359 countsByYear W21492413592019 @default.
- W2149241359 countsByYear W21492413592020 @default.
- W2149241359 countsByYear W21492413592021 @default.
- W2149241359 countsByYear W21492413592022 @default.
- W2149241359 countsByYear W21492413592023 @default.
- W2149241359 crossrefType "journal-article" @default.
- W2149241359 hasAuthorship W2149241359A5007435240 @default.
- W2149241359 hasAuthorship W2149241359A5026224502 @default.
- W2149241359 hasAuthorship W2149241359A5091464419 @default.
- W2149241359 hasBestOaLocation W21492413591 @default.
- W2149241359 hasConcept C104317684 @default.
- W2149241359 hasConcept C142724271 @default.
- W2149241359 hasConcept C143065580 @default.
- W2149241359 hasConcept C153911025 @default.
- W2149241359 hasConcept C2779616913 @default.
- W2149241359 hasConcept C2780852648 @default.
- W2149241359 hasConcept C2781289450 @default.
- W2149241359 hasConcept C547475151 @default.
- W2149241359 hasConcept C55493867 @default.
- W2149241359 hasConcept C71924100 @default.
- W2149241359 hasConcept C86803240 @default.
- W2149241359 hasConcept C89423630 @default.
- W2149241359 hasConceptScore W2149241359C104317684 @default.
- W2149241359 hasConceptScore W2149241359C142724271 @default.
- W2149241359 hasConceptScore W2149241359C143065580 @default.
- W2149241359 hasConceptScore W2149241359C153911025 @default.
- W2149241359 hasConceptScore W2149241359C2779616913 @default.
- W2149241359 hasConceptScore W2149241359C2780852648 @default.
- W2149241359 hasConceptScore W2149241359C2781289450 @default.
- W2149241359 hasConceptScore W2149241359C547475151 @default.
- W2149241359 hasConceptScore W2149241359C55493867 @default.
- W2149241359 hasConceptScore W2149241359C71924100 @default.
- W2149241359 hasConceptScore W2149241359C86803240 @default.
- W2149241359 hasConceptScore W2149241359C89423630 @default.
- W2149241359 hasIssue "6" @default.
- W2149241359 hasLocation W21492413591 @default.
- W2149241359 hasLocation W21492413592 @default.
- W2149241359 hasLocation W21492413593 @default.
- W2149241359 hasOpenAccess W2149241359 @default.
- W2149241359 hasPrimaryLocation W21492413591 @default.
- W2149241359 hasRelatedWork W171739003 @default.
- W2149241359 hasRelatedWork W2059148497 @default.
- W2149241359 hasRelatedWork W2130545881 @default.
- W2149241359 hasRelatedWork W2149241359 @default.
- W2149241359 hasRelatedWork W2151711712 @default.
- W2149241359 hasRelatedWork W2414166055 @default.
- W2149241359 hasRelatedWork W3083580023 @default.
- W2149241359 hasRelatedWork W3112380051 @default.
- W2149241359 hasRelatedWork W3120983736 @default.
- W2149241359 hasRelatedWork W3217740760 @default.
- W2149241359 hasVolume "65" @default.
- W2149241359 isParatext "false" @default.
- W2149241359 isRetracted "false" @default.
- W2149241359 magId "2149241359" @default.
- W2149241359 workType "article" @default.