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- W2149241520 abstract "Although bone morphogenetic protein‐2 (BMP‐2) has received considerable attention because of its strong osteoinductivity, the clinical application of BMP‐2 is limited due to its degradation and deactivation under physiological conditions. Negatively charged heparin is known to form polyelectrolyte complexes with BMP‐2 to prevent deactivation and enhance the osteoinduction capability of BMP‐2. Herein, we report the sulfonated polyrotaxanes (S‐PRX) composed of α‐cyclodextrin threaded onto a linear polymer for the protection of BMP‐2 through the polyelectrolyte complex formation. When MC3T3‐E1 osteoprogenitor cells were treated with the S‐PRX/BMP‐2 complexes, significantly high alkaline phosphatase production and mineralized matrix deposition were observed compared with that of free BMP‐2 and heparin/BMP‐2 complexes. Note that the S‐PRXs showed negligible anticoagulant activity and cytotoxicity, whereas heparin showed strong anticoagulant activity. Accordingly, the S‐PRXs are promising candidates for enhanced osteoinduction ability of BMP‐2 without toxicity and anticoagulant activity and could contribute to clinical bone regeneration." @default.
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- W2149241520 date "2015-03-23" @default.
- W2149241520 modified "2023-10-05" @default.
- W2149241520 title "Supramolecular Polyelectrolyte Complexes of Bone Morphogenetic Protein-2 with Sulfonated Polyrotaxanes to Induce Enhanced Osteogenic Differentiation" @default.
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- W2149241520 doi "https://doi.org/10.1002/mabi.201500032" @default.
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