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- W2149244170 abstract "Virtual screening was used to find replacements for aminoglycoside antibiotics that are able to block in vitrotranscription and translation. A pseudoreceptor model retrieved potent vanilloid derivatives as sugar-mimics. These bioactive antibiotic agents were retrieved by a two-step virtual screening process. ‘Fuzzy’ pharmacophore models allowed for finding alternative chemotypes with lower structural complexity and greater synthetic accessibility than the query." @default.
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- W2149244170 date "2011-01-01" @default.
- W2149244170 modified "2023-09-23" @default.
- W2149244170 title "Scaffold-hopping from aminoglycosides to small synthetic inhibitors of bacterial protein biosynthesis using a pseudoreceptor model" @default.
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- W2149244170 doi "https://doi.org/10.1039/c0md00207k" @default.
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