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• W2149248302 abstract "Background There is conflicting evidence about the relationship between vitamin D deficiency and depression, and a systematic assessment of the literature has not been available. Aims To determine the relationship, if any, between vitamin D deficiency and depression. Method A systematic review and meta-analysis of observational studies and randomised controlled trials was conducted. Results One case-control study, ten cross-sectional studies and three cohort studies with a total of 31 424 participants were analysed. Lower vitamin D levels were found in people with depression compared with controls (SMD = 0.60,95% Cl 0.23–0.97) and there was an increased odds ratio of depression for the lowest v. highest vitamin D categories in the cross-sectional studies (OR = 1.31, 95% CI 1.0–1.71). The cohort studies showed a significantly increased hazard ratio of depression for the lowest v. highest vitamin D categories (HR=2.21, 95% CI 1.40–3.49). Conclusions Our analyses are consistent with the hypothesis that low vitamin D concentration is associated with depression, and highlight the need for randomised controlled trials of vitamin D for the prevention and treatment of depression to determine whether this association is causal." @default.
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• W2149248302 date "2013-02-01" @default.
• W2149248302 modified "2023-10-18" @default.
• W2149248302 title "Vitamin D deficiency and depression in adults: systematic review and meta-analysis" @default.
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• W2149248302 doi "https://doi.org/10.1192/bjp.bp.111.106666" @default.
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