FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149248613> ?p ?o ?g. }

• W2149248613 endingPage "2615" @default.
• W2149248613 startingPage "2607" @default.
• W2149248613 abstract "Development of chemoresistance limits the clinical efficiency of platinum-based therapy. Although many resistance mechanisms have been demonstrated, genetic/molecular alterations responsible for drug resistance in the majority of clinical cases have not been identified. We analyzed three pairs of testicular germ cell tumor cell lines using Affymetrix expression microarrays and revealed a limited number of differentially expressed genes across the cell lines when comparing the parental and resistant cells. Among them, CCND1 was the most significantly differentially expressed gene. Analysis of testicular germ cell tumor clinical samples by quantitative reverse transcription PCR analysis revealed that overall expression of CCND1 was significantly higher in resistant cases compared with sensitive samples (P < 0.0001). We also found that CCND1 was dramatically overexpressed both in induced and intrinsically resistant samples of ovarian and prostate cancer. Finally combined CCND1 knockdown using small-interfering RNA and cisplatin treatment inhibited cell growth in vitro significantly more effectively than any of these single treatments. Therefore, deregulation of CCND1 may be a major cause of cisplatin resistance in testicular germ cell tumors and may also be implicated in ovarian and prostate cancers. CCND1 could be potentially used as a marker for treatment stratification and as a molecular target to improve the treatment of platinum-resistant tumors." @default.
• W2149248613 created "2016-06-24" @default.
• W2149248613 creator A5000054497 @default.
• W2149248613 creator A5012800133 @default.
• W2149248613 creator A5020608500 @default.
• W2149248613 creator A5027640771 @default.
• W2149248613 creator A5030127557 @default.
• W2149248613 creator A5030641434 @default.
• W2149248613 creator A5030753829 @default.
• W2149248613 creator A5031145709 @default.
• W2149248613 creator A5032565350 @default.
• W2149248613 creator A5042160483 @default.
• W2149248613 creator A5046536351 @default.
• W2149248613 creator A5048020168 @default.
• W2149248613 creator A5053529963 @default.
• W2149248613 creator A5056321641 @default.
• W2149248613 creator A5063866219 @default.
• W2149248613 creator A5074984909 @default.
• W2149248613 creator A5075096091 @default.
• W2149248613 creator A5077211569 @default.
• W2149248613 date "2010-06-01" @default.
• W2149248613 modified "2023-10-13" @default.
• W2149248613 title "The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers" @default.
• W2149248613 cites W1522997539 @default.
• W2149248613 cites W1578859370 @default.
• W2149248613 cites W1976863434 @default.
• W2149248613 cites W1979805366 @default.
• W2149248613 cites W1980234430 @default.
• W2149248613 cites W1983708481 @default.
• W2149248613 cites W2002339899 @default.
• W2149248613 cites W2003003988 @default.
• W2149248613 cites W2004467576 @default.
• W2149248613 cites W2004786393 @default.
• W2149248613 cites W2005655696 @default.
• W2149248613 cites W2008094668 @default.
• W2149248613 cites W2017698244 @default.
• W2149248613 cites W2021789591 @default.
• W2149248613 cites W2023519483 @default.
• W2149248613 cites W2038170131 @default.
• W2149248613 cites W2039814783 @default.
• W2149248613 cites W2042541486 @default.
• W2149248613 cites W2051808614 @default.
• W2149248613 cites W2058774033 @default.
• W2149248613 cites W2071641249 @default.
• W2149248613 cites W2074221036 @default.
• W2149248613 cites W2089934507 @default.
• W2149248613 cites W2093350116 @default.
• W2149248613 cites W2106686632 @default.
• W2149248613 cites W2108769689 @default.
• W2149248613 cites W2112845420 @default.
• W2149248613 cites W2123505548 @default.
• W2149248613 cites W2126273255 @default.
• W2149248613 cites W2130177169 @default.
• W2149248613 cites W2132108324 @default.
• W2149248613 cites W2136575012 @default.
• W2149248613 cites W2148859095 @default.
• W2149248613 cites W2149873978 @default.
• W2149248613 cites W2161186839 @default.
• W2149248613 cites W2170454539 @default.
• W2149248613 cites W2320028767 @default.
• W2149248613 cites W4246813829 @default.
• W2149248613 cites W900569881 @default.
• W2149248613 doi "https://doi.org/10.2353/ajpath.2010.090780" @default.
• W2149248613 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2877824" @default.
• W2149248613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20395447" @default.
• W2149248613 hasPublicationYear "2010" @default.
• W2149248613 type Work @default.
• W2149248613 sameAs 2149248613 @default.
• W2149248613 citedByCount "88" @default.
• W2149248613 countsByYear W21492486132012 @default.
• W2149248613 countsByYear W21492486132013 @default.
• W2149248613 countsByYear W21492486132014 @default.
• W2149248613 countsByYear W21492486132015 @default.
• W2149248613 countsByYear W21492486132016 @default.
• W2149248613 countsByYear W21492486132017 @default.
• W2149248613 countsByYear W21492486132018 @default.
• W2149248613 countsByYear W21492486132019 @default.
• W2149248613 countsByYear W21492486132020 @default.
• W2149248613 countsByYear W21492486132021 @default.
• W2149248613 countsByYear W21492486132022 @default.
• W2149248613 countsByYear W21492486132023 @default.
• W2149248613 crossrefType "journal-article" @default.
• W2149248613 hasAuthorship W2149248613A5000054497 @default.
• W2149248613 hasAuthorship W2149248613A5012800133 @default.
• W2149248613 hasAuthorship W2149248613A5020608500 @default.
• W2149248613 hasAuthorship W2149248613A5027640771 @default.
• W2149248613 hasAuthorship W2149248613A5030127557 @default.
• W2149248613 hasAuthorship W2149248613A5030641434 @default.
• W2149248613 hasAuthorship W2149248613A5030753829 @default.
• W2149248613 hasAuthorship W2149248613A5031145709 @default.
• W2149248613 hasAuthorship W2149248613A5032565350 @default.
• W2149248613 hasAuthorship W2149248613A5042160483 @default.
• W2149248613 hasAuthorship W2149248613A5046536351 @default.
• W2149248613 hasAuthorship W2149248613A5048020168 @default.
• W2149248613 hasAuthorship W2149248613A5053529963 @default.
• W2149248613 hasAuthorship W2149248613A5056321641 @default.
• W2149248613 hasAuthorship W2149248613A5063866219 @default.
• W2149248613 hasAuthorship W2149248613A5074984909 @default.

• next