FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149250011> ?p ?o ?g. }

• W2149250011 endingPage "2012" @default.
• W2149250011 startingPage "1999" @default.
• W2149250011 abstract "The sarcin-ricin loop (SRL) of 23S rRNA in the large ribosomal subunit is a factor-binding site that is essential for GTP-catalyzed steps in translation, but its precise functional role is thus far unknown. Here, we replaced the 15-nucleotide SRL with a GAAA tetraloop and affinity purified the mutant 50S subunits for functional and structural analysis in vitro. The SRL deletion caused defects in elongation-factor-dependent steps of translation and, unexpectedly, loss of EF-Tu-independent A-site tRNA binding. Detailed chemical probing analysis showed disruption of a network of rRNA tertiary interactions that hold together the 23S rRNA elements of the functional core of the 50S subunit, accompanied by loss of ribosomal protein L16. Our results reveal an influence of the SRL on the higher-order structure of the 50S subunit, with implications for its role in translation." @default.
• W2149250011 created "2016-06-24" @default.
• W2149250011 creator A5013176795 @default.
• W2149250011 creator A5048211918 @default.
• W2149250011 creator A5075589457 @default.
• W2149250011 creator A5085910904 @default.
• W2149250011 creator A5089776171 @default.
• W2149250011 date "2008-08-28" @default.
• W2149250011 modified "2023-10-01" @default.
• W2149250011 title "The sarcin–ricin loop of 23S rRNA is essential for assembly of the functional core of the 50S ribosomal subunit" @default.
• W2149250011 cites W1417990404 @default.
• W2149250011 cites W1482431053 @default.
• W2149250011 cites W1486369891 @default.
• W2149250011 cites W1498690712 @default.
• W2149250011 cites W1504062513 @default.
• W2149250011 cites W1516634087 @default.
• W2149250011 cites W1966765568 @default.
• W2149250011 cites W1970107043 @default.
• W2149250011 cites W1971809659 @default.
• W2149250011 cites W1973776965 @default.
• W2149250011 cites W1974452426 @default.
• W2149250011 cites W1975085160 @default.
• W2149250011 cites W1975455557 @default.
• W2149250011 cites W1979048982 @default.
• W2149250011 cites W1983534198 @default.
• W2149250011 cites W1984936999 @default.
• W2149250011 cites W1985275120 @default.
• W2149250011 cites W1986714107 @default.
• W2149250011 cites W1989363160 @default.
• W2149250011 cites W1991136545 @default.
• W2149250011 cites W1993888178 @default.
• W2149250011 cites W1996319501 @default.
• W2149250011 cites W1999497853 @default.
• W2149250011 cites W2008026560 @default.
• W2149250011 cites W2008053307 @default.
• W2149250011 cites W2013902881 @default.
• W2149250011 cites W2020105636 @default.
• W2149250011 cites W2022754910 @default.
• W2149250011 cites W2022895983 @default.
• W2149250011 cites W2026358434 @default.
• W2149250011 cites W2029026643 @default.
• W2149250011 cites W2031225710 @default.
• W2149250011 cites W2031799761 @default.
• W2149250011 cites W2035935848 @default.
• W2149250011 cites W2036931150 @default.
• W2149250011 cites W2037870900 @default.
• W2149250011 cites W2039723995 @default.
• W2149250011 cites W2040037553 @default.
• W2149250011 cites W2040441524 @default.
• W2149250011 cites W2041188328 @default.
• W2149250011 cites W2045355648 @default.
• W2149250011 cites W2054511300 @default.
• W2149250011 cites W2060419010 @default.
• W2149250011 cites W2064560761 @default.
• W2149250011 cites W2066613705 @default.
• W2149250011 cites W2066906496 @default.
• W2149250011 cites W2069006508 @default.
• W2149250011 cites W2071877490 @default.
• W2149250011 cites W2073149987 @default.
• W2149250011 cites W2081540493 @default.
• W2149250011 cites W2082583578 @default.
• W2149250011 cites W2085289284 @default.
• W2149250011 cites W2087416703 @default.
• W2149250011 cites W2093041571 @default.
• W2149250011 cites W2093091879 @default.
• W2149250011 cites W2093471887 @default.
• W2149250011 cites W2097654784 @default.
• W2149250011 cites W2100785384 @default.
• W2149250011 cites W2113338791 @default.
• W2149250011 cites W2117808511 @default.
• W2149250011 cites W2136322092 @default.
• W2149250011 cites W2137206793 @default.
• W2149250011 cites W2145583354 @default.
• W2149250011 cites W2148417715 @default.
• W2149250011 cites W2156021317 @default.
• W2149250011 cites W2158314430 @default.
• W2149250011 cites W2284793573 @default.
• W2149250011 cites W3020832836 @default.
• W2149250011 cites W4239023878 @default.
• W2149250011 cites W4251684055 @default.
• W2149250011 cites W1965898972 @default.
• W2149250011 doi "https://doi.org/10.1261/rna.1202108" @default.
• W2149250011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2553751" @default.
• W2149250011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18755834" @default.
• W2149250011 hasPublicationYear "2008" @default.
• W2149250011 type Work @default.
• W2149250011 sameAs 2149250011 @default.
• W2149250011 citedByCount "49" @default.
• W2149250011 countsByYear W21492500112012 @default.
• W2149250011 countsByYear W21492500112013 @default.
• W2149250011 countsByYear W21492500112014 @default.
• W2149250011 countsByYear W21492500112015 @default.
• W2149250011 countsByYear W21492500112016 @default.
• W2149250011 countsByYear W21492500112017 @default.
• W2149250011 countsByYear W21492500112018 @default.
• W2149250011 countsByYear W21492500112019 @default.
• W2149250011 countsByYear W21492500112020 @default.
• W2149250011 countsByYear W21492500112021 @default.

• next