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• W2149251878 startingPage "684" @default.
• W2149251878 abstract "Telomeres are nucleoprotein structures capping the physical ends of linear eukaryotic chromosomes. Although largely heterochromatic, telomeres are transcribed into telomeric repeat-containing RNA (TERRA) molecules by RNA polymerase II. The functions associated with telomere transcription and TERRA remain ill defined. Here we show that the transcriptional activity of human telomeres directly regulates their movement during interphase. We find that chemical inhibition of global transcription dampens telomere motion, while global stimulation promotes it. Likewise, when DNA methyltransferase enzymes are deleted to augment telomere transcription, we observe increased telomere movement. Finally, using a cell line engineered with a unique transcriptionally inducible telomere, we show that transcription of one specific telomere stimulates only its own dynamics without overtly affecting its stability or its length. We reveal a new and unforeseen function for telomere transcription as a regulator of telomere motion, and speculate on the intriguing possibility that transcription-dependent telomere motion sustains the maintenance of functional and dysfunctional telomeres." @default.
• W2149251878 created "2016-06-24" @default.
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• W2149251878 date "2012-02-22" @default.
• W2149251878 modified "2023-10-09" @default.
• W2149251878 title "Transcription regulates telomere dynamics in human cancer cells" @default.
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• W2149251878 doi "https://doi.org/10.1261/rna.029587.111" @default.
• W2149251878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3312556" @default.
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