Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149252002> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2149252002 endingPage "960" @default.
- W2149252002 startingPage "954" @default.
- W2149252002 abstract "Leptin, the product of the ob gene, regulates food intake, energy expenditure, and other physiological functions of the peripheral tissues. Leptin receptors have been identified in the hypothalamus and in extrahypothalamic tissues. Increased circulating leptin levels have been correlated with cardiovascular disease, obesity, aging, infection with bacterial lipopolysaccharide, and high-fat diets. All these conditions have also been correlated with increased vascular calcification, a hallmark of atherosclerotic and age-related vascular disease. In addition, the differentiation of marrow osteoprogenitor cells is regulated by leptin. Thus, we hypothesized that leptin may regulate the calcification of vascular cells. In this report, we tested the effects of leptin on a previously characterized subpopulation of vascular cells that undergo osteoblastic differentiation and calcification in vitro. When treated with leptin, these calcifying vascular cells had a significant 5- to 10-fold increase in alkaline phosphatase activity, a marker of osteogenic differentiation of osteoblastic cells. Prolonged treatment with leptin enhanced the calcification of these cells, further supporting the pro-osteogenic differentiation effects of leptin. Furthermore, the presence of the leptin receptor on calcifying vascular cells was demonstrated using reverse transcriptase polymerase chain reaction, immunocytochemistry, and Western blot analysis. We also identified the presence of leptin receptor in the mouse artery wall, localized to subpopulations of medial and adventitial cells, and the expression of leptin by artery wall cells and atherosclerotic lesions in mice. Taken together, these results suggest that leptin regulates the osteoblastic differentiation and calcification of vascular cells and that the artery wall may be an important peripheral tissue target of leptin action." @default.
- W2149252002 created "2016-06-24" @default.
- W2149252002 creator A5015151481 @default.
- W2149252002 creator A5040164343 @default.
- W2149252002 creator A5055814978 @default.
- W2149252002 creator A5059995837 @default.
- W2149252002 creator A5062873812 @default.
- W2149252002 date "2001-05-11" @default.
- W2149252002 modified "2023-10-03" @default.
- W2149252002 title "Leptin Enhances the Calcification of Vascular Cells" @default.
- W2149252002 cites W1967850325 @default.
- W2149252002 cites W1968564893 @default.
- W2149252002 cites W2000279901 @default.
- W2149252002 cites W2002689024 @default.
- W2149252002 cites W2004861927 @default.
- W2149252002 cites W2014163208 @default.
- W2149252002 cites W2016994959 @default.
- W2149252002 cites W2047014086 @default.
- W2149252002 cites W2057883211 @default.
- W2149252002 cites W2059092365 @default.
- W2149252002 cites W2075906628 @default.
- W2149252002 cites W2079538912 @default.
- W2149252002 cites W2080447461 @default.
- W2149252002 cites W2096211563 @default.
- W2149252002 cites W2100835537 @default.
- W2149252002 cites W2109311297 @default.
- W2149252002 cites W2110190976 @default.
- W2149252002 cites W2126426760 @default.
- W2149252002 cites W2146675158 @default.
- W2149252002 cites W2148802521 @default.
- W2149252002 cites W2153785016 @default.
- W2149252002 cites W2167848739 @default.
- W2149252002 doi "https://doi.org/10.1161/hh0901.090975" @default.
- W2149252002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11349006" @default.
- W2149252002 hasPublicationYear "2001" @default.
- W2149252002 type Work @default.
- W2149252002 sameAs 2149252002 @default.
- W2149252002 citedByCount "283" @default.
- W2149252002 countsByYear W21492520022012 @default.
- W2149252002 countsByYear W21492520022013 @default.
- W2149252002 countsByYear W21492520022014 @default.
- W2149252002 countsByYear W21492520022015 @default.
- W2149252002 countsByYear W21492520022016 @default.
- W2149252002 countsByYear W21492520022017 @default.
- W2149252002 countsByYear W21492520022018 @default.
- W2149252002 countsByYear W21492520022019 @default.
- W2149252002 countsByYear W21492520022020 @default.
- W2149252002 countsByYear W21492520022021 @default.
- W2149252002 countsByYear W21492520022022 @default.
- W2149252002 countsByYear W21492520022023 @default.
- W2149252002 crossrefType "journal-article" @default.
- W2149252002 hasAuthorship W2149252002A5015151481 @default.
- W2149252002 hasAuthorship W2149252002A5040164343 @default.
- W2149252002 hasAuthorship W2149252002A5055814978 @default.
- W2149252002 hasAuthorship W2149252002A5059995837 @default.
- W2149252002 hasAuthorship W2149252002A5062873812 @default.
- W2149252002 hasConcept C126322002 @default.
- W2149252002 hasConcept C134018914 @default.
- W2149252002 hasConcept C14372207 @default.
- W2149252002 hasConcept C170493617 @default.
- W2149252002 hasConcept C171089720 @default.
- W2149252002 hasConcept C2780007613 @default.
- W2149252002 hasConcept C2780309369 @default.
- W2149252002 hasConcept C2780613262 @default.
- W2149252002 hasConcept C511355011 @default.
- W2149252002 hasConcept C71924100 @default.
- W2149252002 hasConcept C86803240 @default.
- W2149252002 hasConceptScore W2149252002C126322002 @default.
- W2149252002 hasConceptScore W2149252002C134018914 @default.
- W2149252002 hasConceptScore W2149252002C14372207 @default.
- W2149252002 hasConceptScore W2149252002C170493617 @default.
- W2149252002 hasConceptScore W2149252002C171089720 @default.
- W2149252002 hasConceptScore W2149252002C2780007613 @default.
- W2149252002 hasConceptScore W2149252002C2780309369 @default.
- W2149252002 hasConceptScore W2149252002C2780613262 @default.
- W2149252002 hasConceptScore W2149252002C511355011 @default.
- W2149252002 hasConceptScore W2149252002C71924100 @default.
- W2149252002 hasConceptScore W2149252002C86803240 @default.
- W2149252002 hasIssue "9" @default.
- W2149252002 hasLocation W21492520021 @default.
- W2149252002 hasLocation W21492520022 @default.
- W2149252002 hasOpenAccess W2149252002 @default.
- W2149252002 hasPrimaryLocation W21492520021 @default.
- W2149252002 hasRelatedWork W1988825782 @default.
- W2149252002 hasRelatedWork W2039286344 @default.
- W2149252002 hasRelatedWork W2056036087 @default.
- W2149252002 hasRelatedWork W2062617116 @default.
- W2149252002 hasRelatedWork W2070380430 @default.
- W2149252002 hasRelatedWork W2099969362 @default.
- W2149252002 hasRelatedWork W2108326265 @default.
- W2149252002 hasRelatedWork W2109467740 @default.
- W2149252002 hasRelatedWork W2344086661 @default.
- W2149252002 hasRelatedWork W2348811830 @default.
- W2149252002 hasVolume "88" @default.
- W2149252002 isParatext "false" @default.
- W2149252002 isRetracted "false" @default.
- W2149252002 magId "2149252002" @default.
- W2149252002 workType "article" @default.