Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149253286> ?p ?o ?g. }
- W2149253286 endingPage "173" @default.
- W2149253286 startingPage "167" @default.
- W2149253286 abstract "Nowadays, the techniques available for chronic Chagas' disease diagnosis are very sensitive; however, they do not allow discrimination of the patient's clinical stages of the disease. The present paper describes that three out of the five different repeats contained in the Trypanosoma cruzi TcCA-2 membrane protein (3972-FGQAAAGDKPPP, 6303-FGQAAAGDKPAP, and 3973-FGQAAAGDKPSL) are recognized with high sensitivity (>90%) by sera from chronic Chagas' disease patients and that they are not recognized by sera from patients in the acute phase of the disease. A total of 133 serum samples from chagasic patients and 50 serum samples from healthy donors were tested. In addition, sera from 15 patients with different autoimmune diseases, 43 serum samples from patients suffering an infectious disease other than Chagas' disease, and 38 serum samples from patients with nonchagasic cardiac disorders were also included in this study. The residue 3973 peptide shows a specificity of >98%, as it is not recognized by individuals with autoimmune and inflammatory processes or by patients with a nonchagasic cardiomyopathy. Remarkably, the levels of antibody against the 3973 epitope detected by the sera from Chagas' disease patients in the symptomatic chronic phase, involving cardiac or digestive alterations, are higher than those detected by the sera from Chagas' disease patients in the indeterminate phase of the disease. It is suggested that the diagnostic technique described could also be used to indicate the degree of pathology. The amino acids F, Q, and DKP located in the peptide at positions 1, 3, and 8 to 10, respectively, are essential to conform to the immunodominant antigenic epitope." @default.
- W2149253286 created "2016-06-24" @default.
- W2149253286 creator A5003809673 @default.
- W2149253286 creator A5028701129 @default.
- W2149253286 creator A5057715038 @default.
- W2149253286 creator A5060042716 @default.
- W2149253286 creator A5065535842 @default.
- W2149253286 creator A5071237849 @default.
- W2149253286 creator A5081881529 @default.
- W2149253286 creator A5082802813 @default.
- W2149253286 creator A5083316697 @default.
- W2149253286 creator A5085247059 @default.
- W2149253286 date "2012-02-01" @default.
- W2149253286 modified "2023-10-10" @default.
- W2149253286 title "Characterization of an Immunodominant Antigenic Epitope from Trypanosoma cruzi as a Biomarker of Chronic Chagas' Disease Pathology" @default.
- W2149253286 cites W1507555635 @default.
- W2149253286 cites W1966622156 @default.
- W2149253286 cites W1970841481 @default.
- W2149253286 cites W1979442081 @default.
- W2149253286 cites W1979885599 @default.
- W2149253286 cites W1990343216 @default.
- W2149253286 cites W1990788531 @default.
- W2149253286 cites W2010360188 @default.
- W2149253286 cites W2012195873 @default.
- W2149253286 cites W2013771584 @default.
- W2149253286 cites W2015647554 @default.
- W2149253286 cites W2019634118 @default.
- W2149253286 cites W2022334324 @default.
- W2149253286 cites W2023838767 @default.
- W2149253286 cites W2044948718 @default.
- W2149253286 cites W2049590994 @default.
- W2149253286 cites W2056512823 @default.
- W2149253286 cites W2063503143 @default.
- W2149253286 cites W2068186993 @default.
- W2149253286 cites W2074784958 @default.
- W2149253286 cites W2080936432 @default.
- W2149253286 cites W2081167480 @default.
- W2149253286 cites W2094954825 @default.
- W2149253286 cites W2105827340 @default.
- W2149253286 cites W2106485985 @default.
- W2149253286 cites W2109145622 @default.
- W2149253286 cites W2119509691 @default.
- W2149253286 cites W2121389836 @default.
- W2149253286 cites W2128450160 @default.
- W2149253286 cites W2132390016 @default.
- W2149253286 cites W2149258299 @default.
- W2149253286 cites W2160079235 @default.
- W2149253286 cites W2163396616 @default.
- W2149253286 cites W2164874656 @default.
- W2149253286 cites W2265581766 @default.
- W2149253286 cites W4210980497 @default.
- W2149253286 cites W4235037199 @default.
- W2149253286 doi "https://doi.org/10.1128/cvi.05566-11" @default.
- W2149253286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3272920" @default.
- W2149253286 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22155766" @default.
- W2149253286 hasPublicationYear "2012" @default.
- W2149253286 type Work @default.
- W2149253286 sameAs 2149253286 @default.
- W2149253286 citedByCount "20" @default.
- W2149253286 countsByYear W21492532862012 @default.
- W2149253286 countsByYear W21492532862013 @default.
- W2149253286 countsByYear W21492532862015 @default.
- W2149253286 countsByYear W21492532862016 @default.
- W2149253286 countsByYear W21492532862017 @default.
- W2149253286 countsByYear W21492532862019 @default.
- W2149253286 countsByYear W21492532862020 @default.
- W2149253286 countsByYear W21492532862021 @default.
- W2149253286 countsByYear W21492532862022 @default.
- W2149253286 countsByYear W21492532862023 @default.
- W2149253286 crossrefType "journal-article" @default.
- W2149253286 hasAuthorship W2149253286A5003809673 @default.
- W2149253286 hasAuthorship W2149253286A5028701129 @default.
- W2149253286 hasAuthorship W2149253286A5057715038 @default.
- W2149253286 hasAuthorship W2149253286A5060042716 @default.
- W2149253286 hasAuthorship W2149253286A5065535842 @default.
- W2149253286 hasAuthorship W2149253286A5071237849 @default.
- W2149253286 hasAuthorship W2149253286A5081881529 @default.
- W2149253286 hasAuthorship W2149253286A5082802813 @default.
- W2149253286 hasAuthorship W2149253286A5083316697 @default.
- W2149253286 hasAuthorship W2149253286A5085247059 @default.
- W2149253286 hasBestOaLocation W21492532861 @default.
- W2149253286 hasConcept C112418997 @default.
- W2149253286 hasConcept C126322002 @default.
- W2149253286 hasConcept C136764020 @default.
- W2149253286 hasConcept C159047783 @default.
- W2149253286 hasConcept C159654299 @default.
- W2149253286 hasConcept C195616568 @default.
- W2149253286 hasConcept C203014093 @default.
- W2149253286 hasConcept C2777625466 @default.
- W2149253286 hasConcept C2779075594 @default.
- W2149253286 hasConcept C2779134260 @default.
- W2149253286 hasConcept C2781197716 @default.
- W2149253286 hasConcept C41008148 @default.
- W2149253286 hasConcept C45189115 @default.
- W2149253286 hasConcept C55493867 @default.
- W2149253286 hasConcept C71924100 @default.
- W2149253286 hasConcept C71928629 @default.
- W2149253286 hasConcept C86803240 @default.