FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149253445> ?p ?o ?g. }

• W2149253445 endingPage "408" @default.
• W2149253445 startingPage "399" @default.
• W2149253445 abstract "At synapses, ATP is released and metabolised through ecto-nucleotidases forming adenosine, which modulates neurotransmitter release through inhibitory A1 or facilitatory A2A receptors, according to the amounts of extracellular adenosine. Neuromuscular junctions possess an ecto-AMP deaminase that can dissociate extracellular ATP catabolism from adenosine formation. In this study we have investigated the pattern of ATP release and its conversion into adenosine, to probe the role of ecto-AMP deaminase in controlling acetylcholine release from rat phrenic nerve terminals. Nerve-evoked ATP release was 28 +/- 12 pmol (mg tissue)-1 at 1 Hz, 54 +/- 3 pmol (mg tissue)-1 at 5 Hz and disproportionally higher at 50 Hz (324 +/- 23 pmol (mg tissue)-1). Extracellular ATP (30 microM) was metabolised with a half time of 8 +/- 2 min, being converted into ADP then into AMP. AMP was either dephosphorylated into adenosine by ecto-5'-nucleotidase (inhibited by ATP and blocked by 200 microM alpha,beta-methylene ADP) or deaminated into IMP by ecto-AMP deaminase (inhibited by 200 microM deoxycoformycin, which increased adenosine formation). Dephosphorylation and deamination pathways also catabolised endogenously released adenine nucleotides, since the nerve-evoked extracellular AMP accumulation was increased by either alpha,beta-methylene ADP (200 microM) or deoxycoformycin (200 microM). In the presence of nitrobenzylthioinosine (30 microM) to inhibit adenosine transport, deoxycoformycin (200 microM) facilitated nerve-evoked [3H]acetylcholine release by 77 +/- 9 %, an effect prevented by the A2A receptor antagonist, ZM 241385 (10 nM). It is concluded that, while ecto-5'-nucleotidase is inhibited by released ATP, ecto-AMP deaminase activity transiently blunts adenosine formation, which would otherwise reach levels high enough to activate facilitatory A2A receptors on motor nerve terminals." @default.
• W2149253445 created "2016-06-24" @default.
• W2149253445 creator A5000881478 @default.
• W2149253445 creator A5016185710 @default.
• W2149253445 creator A5027179349 @default.
• W2149253445 creator A5030328456 @default.
• W2149253445 creator A5047426407 @default.
• W2149253445 creator A5058483077 @default.
• W2149253445 date "2003-06-01" @default.
• W2149253445 modified "2023-10-15" @default.
• W2149253445 title "Ecto‐AMP Deaminase Blunts the ATP‐Derived Adenosine A_2A Receptor Facilitation of Acetylcholine Release at Rat Motor Nerve Endings" @default.
• W2149253445 cites W1500031052 @default.
• W2149253445 cites W1556609980 @default.
• W2149253445 cites W1557275969 @default.
• W2149253445 cites W1560216123 @default.
• W2149253445 cites W1578187871 @default.
• W2149253445 cites W1620679902 @default.
• W2149253445 cites W1966394816 @default.
• W2149253445 cites W1967199758 @default.
• W2149253445 cites W1968921660 @default.
• W2149253445 cites W1973964837 @default.
• W2149253445 cites W1974669601 @default.
• W2149253445 cites W1976273184 @default.
• W2149253445 cites W1976361922 @default.
• W2149253445 cites W1985487317 @default.
• W2149253445 cites W2001514080 @default.
• W2149253445 cites W2011605302 @default.
• W2149253445 cites W2012802654 @default.
• W2149253445 cites W2022901421 @default.
• W2149253445 cites W2032611621 @default.
• W2149253445 cites W2040414052 @default.
• W2149253445 cites W2050330888 @default.
• W2149253445 cites W2053269045 @default.
• W2149253445 cites W2053989667 @default.
• W2149253445 cites W2055771038 @default.
• W2149253445 cites W2065264970 @default.
• W2149253445 cites W2069488037 @default.
• W2149253445 cites W2077535383 @default.
• W2149253445 cites W2078723347 @default.
• W2149253445 cites W2081486880 @default.
• W2149253445 cites W2083234608 @default.
• W2149253445 cites W2084900060 @default.
• W2149253445 cites W2086611782 @default.
• W2149253445 cites W2094215061 @default.
• W2149253445 cites W2101742519 @default.
• W2149253445 cites W2137648115 @default.
• W2149253445 cites W2143564080 @default.
• W2149253445 cites W2157714782 @default.
• W2149253445 cites W2279450809 @default.
• W2149253445 cites W2414492671 @default.
• W2149253445 cites W53455726 @default.
• W2149253445 cites W54538561 @default.
• W2149253445 doi "https://doi.org/10.1113/jphysiol.2003.040410" @default.
• W2149253445 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2342942" @default.
• W2149253445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12679375" @default.
• W2149253445 hasPublicationYear "2003" @default.
• W2149253445 type Work @default.
• W2149253445 sameAs 2149253445 @default.
• W2149253445 citedByCount "52" @default.
• W2149253445 countsByYear W21492534452012 @default.
• W2149253445 countsByYear W21492534452013 @default.
• W2149253445 countsByYear W21492534452014 @default.
• W2149253445 countsByYear W21492534452015 @default.
• W2149253445 countsByYear W21492534452016 @default.
• W2149253445 countsByYear W21492534452017 @default.
• W2149253445 countsByYear W21492534452019 @default.
• W2149253445 countsByYear W21492534452020 @default.
• W2149253445 countsByYear W21492534452021 @default.
• W2149253445 countsByYear W21492534452022 @default.
• W2149253445 countsByYear W21492534452023 @default.
• W2149253445 crossrefType "journal-article" @default.
• W2149253445 hasAuthorship W2149253445A5000881478 @default.
• W2149253445 hasAuthorship W2149253445A5016185710 @default.
• W2149253445 hasAuthorship W2149253445A5027179349 @default.
• W2149253445 hasAuthorship W2149253445A5030328456 @default.
• W2149253445 hasAuthorship W2149253445A5047426407 @default.
• W2149253445 hasAuthorship W2149253445A5058483077 @default.
• W2149253445 hasBestOaLocation W21492534452 @default.
• W2149253445 hasConcept C104317684 @default.
• W2149253445 hasConcept C126322002 @default.
• W2149253445 hasConcept C134018914 @default.
• W2149253445 hasConcept C165912504 @default.
• W2149253445 hasConcept C170493617 @default.
• W2149253445 hasConcept C172590197 @default.
• W2149253445 hasConcept C182683403 @default.
• W2149253445 hasConcept C185592680 @default.
• W2149253445 hasConcept C2775910092 @default.
• W2149253445 hasConcept C2776991684 @default.
• W2149253445 hasConcept C2778938600 @default.
• W2149253445 hasConcept C28406088 @default.
• W2149253445 hasConcept C2909627636 @default.
• W2149253445 hasConcept C2910277799 @default.
• W2149253445 hasConcept C2994266630 @default.
• W2149253445 hasConcept C34628245 @default.
• W2149253445 hasConcept C512185932 @default.
• W2149253445 hasConcept C55493867 @default.
• W2149253445 hasConcept C67907053 @default.
• W2149253445 hasConcept C71924100 @default.

• next