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- W2149253966 abstract "Rationale: Exposure to particulate matter l2.5μ in diameter (PM 2.5 ) has been associated with increased mortality. After inhalation, PM 2.5 may have direct effects on the pulmonary circulation. We hypothesized that PM 2.5 exposure would be associated with pulmonary vascular changes on CT in a large population-based study. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled participants 45-84 years old without clinical cardiovascular disease. The MESA Lung Study measured total pulmonary vascular volume (TPVV) on non-contrast CT. TPVV is the sum of the volumes of arteries and veins (≥ approx. 1mm) per unit lung in the 2cm “peel” (Figure). Exposures to outdoor residential PM 2.5 in the year prior to CT were estimated by a spatiotemporal model. Linear regression adjusted for age, sex, race, education, height, weight, smoking and scanner terms. Results: Mean PM 2.5 exposure of the 2675 participants (69±9 years, 47% male, 46% never smokers) was 11.1±1.5 μg/m 3 . Mean TPVV was 2.29 cm 3 vessel/cm 3 lung. In the fully adjusted model a 5 μg/m 3 increase in PM 2.5 was associated with an increase in TPVV (0.06 cm 3 vessel/cm 3 lung; Pl0.001). Conclusions: Exposure to PM 2.5 was associated with increased TPVV, suggesting that PM 2.5 may contribute to pulmonary vascular changes including microvascular damage." @default.
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- W2149253966 date "2014-09-01" @default.
- W2149253966 modified "2023-09-26" @default.
- W2149253966 title "Particulate matter exposure and differences in pulmonary vascular structure: The MESA lung and air pollution studies" @default.
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