FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149254293> ?p ?o ?g. }

• W2149254293 endingPage "61" @default.
• W2149254293 startingPage "52" @default.
• W2149254293 abstract "Rationale: Apoptotic cell phagocytosis (efferocytosis) is mediated by specific receptors and is essential for resolution of inflammation. In chronic inflammation, apoptotic cell clearance is dysfunctional and soluble levels of several apoptotic cell receptors are elevated. Reports have identified proteolytic cleavage as a mechanism capable of releasing soluble apoptotic cell receptors, but the functional implications of their proteolysis are unclear. Objective: To test the hypothesis that ADAM17-mediated cleavage of apoptotic cell receptors limits efferocytosis in vivo. Methods and Results: In vivo comparison of macrophage efferocytosis in wild-type and Adam17 -null hematopoietic chimeras demonstrates that ADAM17 deficiency leads to a 60% increase in efferocytosis and an enhanced anti-inflammatory phenotype in a model of peritonitis. In vitro uptake of phosphatidylserine liposomes identifies the dual-pass apoptotic cell receptor CD36 as a major contributor to enhanced efferocytosis, and CD36 surface levels are elevated on macrophages from Adam17 -null mice. Further, temporal elevation of CD36 expression with inflammation may also contribute to its impact. Soluble CD36 from macrophage-conditioned media comprises 2 species based on Western blotting, and mass spectrometry identifies 3 N-terminal peptides that represent probable cleavage sites. Levels of soluble CD36 are decreased in Adam17 -null conditioned media, providing evidence for involvement of ADAM17 in CD36 cleavage. Importantly, enhanced efferocytosis in vivo by macrophages lacking ADAM17 is CD36 dependent and accelerates macrophage clearance from the peritoneum, thus promoting resolution of inflammation and highlighting the impact of increased apoptotic cell uptake. Conclusions: Our studies demonstrate the importance of ADAM17-mediated proteolysis for in vivo efferocytosis regulation and suggest a possible mechanistic link between chronic inflammation and defective efferocytosis." @default.
• W2149254293 created "2016-06-24" @default.
• W2149254293 creator A5013488126 @default.
• W2149254293 creator A5035813072 @default.
• W2149254293 creator A5053470073 @default.
• W2149254293 creator A5085075726 @default.
• W2149254293 creator A5090275884 @default.
• W2149254293 date "2013-06-21" @default.
• W2149254293 modified "2023-10-15" @default.
• W2149254293 title "Macrophage ADAM17 Deficiency Augments CD36-Dependent Apoptotic Cell Uptake and the Linked Anti-Inflammatory Phenotype" @default.
• W2149254293 cites W1570009716 @default.
• W2149254293 cites W1608305635 @default.
• W2149254293 cites W1762420699 @default.
• W2149254293 cites W1994231923 @default.
• W2149254293 cites W1994916925 @default.
• W2149254293 cites W2002812554 @default.
• W2149254293 cites W2007627264 @default.
• W2149254293 cites W2009263722 @default.
• W2149254293 cites W2011178652 @default.
• W2149254293 cites W2012936436 @default.
• W2149254293 cites W2019771217 @default.
• W2149254293 cites W2024131238 @default.
• W2149254293 cites W2028145006 @default.
• W2149254293 cites W2036842448 @default.
• W2149254293 cites W2046234969 @default.
• W2149254293 cites W2056601905 @default.
• W2149254293 cites W2056912931 @default.
• W2149254293 cites W2056914993 @default.
• W2149254293 cites W2057324893 @default.
• W2149254293 cites W2074102438 @default.
• W2149254293 cites W2074881372 @default.
• W2149254293 cites W2084391700 @default.
• W2149254293 cites W2090030808 @default.
• W2149254293 cites W2099635702 @default.
• W2149254293 cites W2110717286 @default.
• W2149254293 cites W2114259322 @default.
• W2149254293 cites W2116572568 @default.
• W2149254293 cites W2127321441 @default.
• W2149254293 cites W2128903448 @default.
• W2149254293 cites W2134101952 @default.
• W2149254293 cites W2134252550 @default.
• W2149254293 cites W2136237697 @default.
• W2149254293 cites W2150473872 @default.
• W2149254293 cites W2153043340 @default.
• W2149254293 cites W2159316425 @default.
• W2149254293 cites W2159325819 @default.
• W2149254293 cites W2163327518 @default.
• W2149254293 cites W2167276755 @default.
• W2149254293 cites W4235300003 @default.
• W2149254293 doi "https://doi.org/10.1161/circresaha.112.300683" @default.
• W2149254293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3693752" @default.
• W2149254293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23584255" @default.
• W2149254293 hasPublicationYear "2013" @default.
• W2149254293 type Work @default.
• W2149254293 sameAs 2149254293 @default.
• W2149254293 citedByCount "68" @default.
• W2149254293 countsByYear W21492542932013 @default.
• W2149254293 countsByYear W21492542932014 @default.
• W2149254293 countsByYear W21492542932015 @default.
• W2149254293 countsByYear W21492542932016 @default.
• W2149254293 countsByYear W21492542932017 @default.
• W2149254293 countsByYear W21492542932018 @default.
• W2149254293 countsByYear W21492542932019 @default.
• W2149254293 countsByYear W21492542932020 @default.
• W2149254293 countsByYear W21492542932021 @default.
• W2149254293 countsByYear W21492542932022 @default.
• W2149254293 countsByYear W21492542932023 @default.
• W2149254293 crossrefType "journal-article" @default.
• W2149254293 hasAuthorship W2149254293A5013488126 @default.
• W2149254293 hasAuthorship W2149254293A5035813072 @default.
• W2149254293 hasAuthorship W2149254293A5053470073 @default.
• W2149254293 hasAuthorship W2149254293A5085075726 @default.
• W2149254293 hasAuthorship W2149254293A5090275884 @default.
• W2149254293 hasBestOaLocation W21492542931 @default.
• W2149254293 hasConcept C1491633281 @default.
• W2149254293 hasConcept C150903083 @default.
• W2149254293 hasConcept C168261976 @default.
• W2149254293 hasConcept C170493617 @default.
• W2149254293 hasConcept C190283241 @default.
• W2149254293 hasConcept C202751555 @default.
• W2149254293 hasConcept C203014093 @default.
• W2149254293 hasConcept C207001950 @default.
• W2149254293 hasConcept C2776914184 @default.
• W2149254293 hasConcept C2779244956 @default.
• W2149254293 hasConcept C2779828298 @default.
• W2149254293 hasConcept C55493867 @default.
• W2149254293 hasConcept C86803240 @default.
• W2149254293 hasConcept C95444343 @default.
• W2149254293 hasConceptScore W2149254293C1491633281 @default.
• W2149254293 hasConceptScore W2149254293C150903083 @default.
• W2149254293 hasConceptScore W2149254293C168261976 @default.
• W2149254293 hasConceptScore W2149254293C170493617 @default.
• W2149254293 hasConceptScore W2149254293C190283241 @default.
• W2149254293 hasConceptScore W2149254293C202751555 @default.
• W2149254293 hasConceptScore W2149254293C203014093 @default.
• W2149254293 hasConceptScore W2149254293C207001950 @default.
• W2149254293 hasConceptScore W2149254293C2776914184 @default.
• W2149254293 hasConceptScore W2149254293C2779244956 @default.

• next