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• W2149256723 abstract "Motor neurons regulate the acetylcholine sensitivity of the muscles they innervate: denervated muscle fiber become supersensitive to acetylcholine, due to insertion of newly synthesized acetylcholine receptors (AChRs) in the plasma membrane. We used hybridization analysis with a cloned cDNA specific for AChR alpha-subunit to compare the abundance of AChR mRNA in innervated and denervated adult mouse muscles. Within 3 d of denervation, levels of AChR mRNA increased 100-fold; levels of actin mRNA changed little. The increase in AChR mRNA level was sufficiently large and rapid to account for denervation supersensitivity." @default.
• W2149256723 created "2016-06-24" @default.
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• W2149256723 date "1984-07-01" @default.
• W2149256723 modified "2023-10-15" @default.
• W2149256723 title "Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe." @default.
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• W2149256723 doi "https://doi.org/10.1083/jcb.99.1.332" @default.
• W2149256723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2275635" @default.
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