Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149261383> ?p ?o ?g. }
- W2149261383 endingPage "1739" @default.
- W2149261383 startingPage "1730" @default.
- W2149261383 abstract "Dependence on tobacco, like many other drug dependencies, is a complex behavior with both genetic and environmental factors contributing to the variance. The heritability estimates for smoking in twin studies have ranged from 46 to 84%, indicating a substantial genetic component to smoking. Candidate gene studies have detected functional polymorphisms in genes coding for the cytochrome P450 enzymes, and variations in these genes that lead to more rapid nicotine metabolism have been implicated in smoking. Similarly, smoking has been associated with polymorphisms in dopaminergic genes that may influence the dopamine receptor number and/or function. Animal experiments have localized specific subunits of the nicotinic receptors that may mediate the reinforcing properties of nicotine and have investigated their role in nicotine dependence. However, environmental factors have also been found to contribute to the risk of initiation and persistence of smoking. We review the scientific evidence that supports a role for genetic influences on smoking, discuss the specific genetic and neurobiological mechanisms that may mediate susceptibility to nicotine dependence, identify possible gene/environmental interactions that may be important in understanding smoking behavior, and suggest directions for future research. Insights into the genetic contributions to smoking can potentially lead to more effective strategies to reduce smoking." @default.
- W2149261383 created "2016-06-24" @default.
- W2149261383 creator A5005681542 @default.
- W2149261383 creator A5017929593 @default.
- W2149261383 creator A5037191310 @default.
- W2149261383 creator A5049894870 @default.
- W2149261383 creator A5079211388 @default.
- W2149261383 date "2003-05-01" @default.
- W2149261383 modified "2023-10-18" @default.
- W2149261383 title "The Genetic Determinants of Smoking" @default.
- W2149261383 cites W110720742 @default.
- W2149261383 cites W136175638 @default.
- W2149261383 cites W1523374635 @default.
- W2149261383 cites W1571140265 @default.
- W2149261383 cites W1587487733 @default.
- W2149261383 cites W1675823061 @default.
- W2149261383 cites W1887217135 @default.
- W2149261383 cites W1966777267 @default.
- W2149261383 cites W1973678939 @default.
- W2149261383 cites W1975564121 @default.
- W2149261383 cites W1978797635 @default.
- W2149261383 cites W1980422898 @default.
- W2149261383 cites W1982164956 @default.
- W2149261383 cites W1984237064 @default.
- W2149261383 cites W1986637631 @default.
- W2149261383 cites W1995769363 @default.
- W2149261383 cites W2000363595 @default.
- W2149261383 cites W2002717125 @default.
- W2149261383 cites W2003786243 @default.
- W2149261383 cites W2005534453 @default.
- W2149261383 cites W2007847139 @default.
- W2149261383 cites W2008179914 @default.
- W2149261383 cites W2008995782 @default.
- W2149261383 cites W2013734734 @default.
- W2149261383 cites W2013918728 @default.
- W2149261383 cites W2014224123 @default.
- W2149261383 cites W2019073365 @default.
- W2149261383 cites W2020114759 @default.
- W2149261383 cites W2024316065 @default.
- W2149261383 cites W2029589558 @default.
- W2149261383 cites W2032807850 @default.
- W2149261383 cites W2033835666 @default.
- W2149261383 cites W2035340433 @default.
- W2149261383 cites W2037482977 @default.
- W2149261383 cites W2037908819 @default.
- W2149261383 cites W2038444868 @default.
- W2149261383 cites W2043109663 @default.
- W2149261383 cites W2043259970 @default.
- W2149261383 cites W2045773309 @default.
- W2149261383 cites W2048346500 @default.
- W2149261383 cites W2052931960 @default.
- W2149261383 cites W2054045315 @default.
- W2149261383 cites W2055139096 @default.
- W2149261383 cites W2065841438 @default.
- W2149261383 cites W2080031511 @default.
- W2149261383 cites W2084032183 @default.
- W2149261383 cites W2085660015 @default.
- W2149261383 cites W2085725480 @default.
- W2149261383 cites W2088829922 @default.
- W2149261383 cites W2090047941 @default.
- W2149261383 cites W2091256944 @default.
- W2149261383 cites W2095630102 @default.
- W2149261383 cites W2097633000 @default.
- W2149261383 cites W2108264967 @default.
- W2149261383 cites W2110395878 @default.
- W2149261383 cites W2111731642 @default.
- W2149261383 cites W2115371904 @default.
- W2149261383 cites W2130648953 @default.
- W2149261383 cites W2142485125 @default.
- W2149261383 cites W2146710322 @default.
- W2149261383 cites W2153455171 @default.
- W2149261383 cites W2157750973 @default.
- W2149261383 cites W2162259068 @default.
- W2149261383 cites W2163199765 @default.
- W2149261383 cites W2166656762 @default.
- W2149261383 cites W2171531223 @default.
- W2149261383 cites W2171822179 @default.
- W2149261383 cites W2296936391 @default.
- W2149261383 cites W2326848859 @default.
- W2149261383 cites W2340141139 @default.
- W2149261383 cites W2403376496 @default.
- W2149261383 cites W4241714769 @default.
- W2149261383 cites W4247190210 @default.
- W2149261383 doi "https://doi.org/10.1378/chest.123.5.1730" @default.
- W2149261383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12740294" @default.
- W2149261383 hasPublicationYear "2003" @default.
- W2149261383 type Work @default.
- W2149261383 sameAs 2149261383 @default.
- W2149261383 citedByCount "172" @default.
- W2149261383 countsByYear W21492613832012 @default.
- W2149261383 countsByYear W21492613832013 @default.
- W2149261383 countsByYear W21492613832014 @default.
- W2149261383 countsByYear W21492613832015 @default.
- W2149261383 countsByYear W21492613832016 @default.
- W2149261383 countsByYear W21492613832017 @default.
- W2149261383 countsByYear W21492613832018 @default.
- W2149261383 countsByYear W21492613832020 @default.
- W2149261383 countsByYear W21492613832021 @default.