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- W2149265260 abstract "RIG-I-like receptors (RLRs) utilize a specialized, multi-domain architecture to detect and respond to invasion by a diverse set of viruses. Structural similarities among these receptors provide a general mechanism for double strand RNA recognition and signal transduction. However, each RLR has developed unique strategies for sensing the specific molecular determinants on subgroups of viral RNAs. As a means to circumvent the antiviral response, viruses escape RLR detection by degrading, or sequestering or modifying their RNA. Patterns of variation in RLR sequence reveal a continuous evolution of the protein domains that contribute to RNA recognition and signaling." @default.
- W2149265260 created "2016-06-24" @default.
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- W2149265260 date "2014-08-01" @default.
- W2149265260 modified "2023-10-01" @default.
- W2149265260 title "An evolving arsenal: viral RNA detection by RIG-I-like receptors" @default.
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- W2149265260 doi "https://doi.org/10.1016/j.mib.2014.05.004" @default.
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