FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2149269875> ?p ?o ?g. }

• W2149269875 endingPage "106" @default.
• W2149269875 startingPage "98" @default.
• W2149269875 abstract "Although recanalization of the infarct-related artery late after myocardial infarction (MI) is known to reduce both cardiac remodeling and mortality, the mechanisms responsible are not yet fully understood. We compared infarcted rat hearts in which the infarct-related coronary artery was opened 24 hours after infarction (late reperfusion [LR] group) with those having a permanently occluded artery. Left ventricular dilatation and dysfunction were significantly mitigated in the LR group 1, 2, and 4 weeks post-MI. Attributable, in large part, to the greater number of cells present, the infarcted wall was significantly thicker in the LR group, which likely reduced wall stress and mitigated cardiac dysfunction. Granulation tissue cell proliferation was increased to a greater degree in the LR group 4 days post-MI, whereas the incidence of apoptosis was significantly lower throughout the subacute stage (4 days, 1 week, and 2 weeks post-MI), further suggesting preservation of granulation tissue cells contributes to the thick, cell-rich scar. Functionally, myocardial debris was more rapidly removed from the infarcted areas in the LR group during subacute stages, and stouter collagen was more rapidly synthesized in those areas. Direct acceleration of Fas-mediated apoptosis by hypoxia was confirmed in vitro using infarct tissue-derived myofibroblasts. In salvaged cardiomyocytes, degenerative changes, but not apoptosis, were mitigated in the LR group, accompanied by restoration of GATA-4 and sarcomeric protein expression. Along with various mechanisms proposed earlier, the present findings appear to provide an additional pathophysiological basis for the benefits of late reperfusion." @default.
• W2149269875 created "2016-06-24" @default.
• W2149269875 creator A5004415631 @default.
• W2149269875 creator A5017327924 @default.
• W2149269875 creator A5022669876 @default.
• W2149269875 creator A5027121786 @default.
• W2149269875 creator A5030175585 @default.
• W2149269875 creator A5038207133 @default.
• W2149269875 creator A5039533635 @default.
• W2149269875 creator A5042104765 @default.
• W2149269875 creator A5046826386 @default.
• W2149269875 creator A5053243830 @default.
• W2149269875 creator A5054902055 @default.
• W2149269875 creator A5058412848 @default.
• W2149269875 creator A5059646387 @default.
• W2149269875 creator A5064440517 @default.
• W2149269875 creator A5066511998 @default.
• W2149269875 creator A5077199917 @default.
• W2149269875 creator A5077773904 @default.
• W2149269875 creator A5087541787 @default.
• W2149269875 creator A5089279058 @default.
• W2149269875 date "2008-07-03" @default.
• W2149269875 modified "2023-10-16" @default.
• W2149269875 title "Mechanisms by Which Late Coronary Reperfusion Mitigates Postinfarction Cardiac Remodeling" @default.
• W2149269875 cites W1934786235 @default.
• W2149269875 cites W1965158741 @default.
• W2149269875 cites W1976570855 @default.
• W2149269875 cites W1991792975 @default.
• W2149269875 cites W2000870731 @default.
• W2149269875 cites W2007665059 @default.
• W2149269875 cites W2022608072 @default.
• W2149269875 cites W2044391218 @default.
• W2149269875 cites W2045946370 @default.
• W2149269875 cites W2051696368 @default.
• W2149269875 cites W2064261225 @default.
• W2149269875 cites W2066675672 @default.
• W2149269875 cites W2074272236 @default.
• W2149269875 cites W2075518730 @default.
• W2149269875 cites W2094494009 @default.
• W2149269875 cites W2108512082 @default.
• W2149269875 cites W2111529958 @default.
• W2149269875 cites W2128694891 @default.
• W2149269875 cites W2134996862 @default.
• W2149269875 cites W2137644977 @default.
• W2149269875 cites W2138794351 @default.
• W2149269875 cites W2146936491 @default.
• W2149269875 cites W2148075660 @default.
• W2149269875 cites W2151513540 @default.
• W2149269875 cites W2152044516 @default.
• W2149269875 cites W2158635027 @default.
• W2149269875 cites W2166894412 @default.
• W2149269875 cites W2340149484 @default.
• W2149269875 doi "https://doi.org/10.1161/circresaha.108.177568" @default.
• W2149269875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18519944" @default.
• W2149269875 hasPublicationYear "2008" @default.
• W2149269875 type Work @default.
• W2149269875 sameAs 2149269875 @default.
• W2149269875 citedByCount "32" @default.
• W2149269875 countsByYear W21492698752012 @default.
• W2149269875 countsByYear W21492698752013 @default.
• W2149269875 countsByYear W21492698752014 @default.
• W2149269875 countsByYear W21492698752015 @default.
• W2149269875 countsByYear W21492698752016 @default.
• W2149269875 countsByYear W21492698752018 @default.
• W2149269875 countsByYear W21492698752019 @default.
• W2149269875 countsByYear W21492698752023 @default.
• W2149269875 crossrefType "journal-article" @default.
• W2149269875 hasAuthorship W2149269875A5004415631 @default.
• W2149269875 hasAuthorship W2149269875A5017327924 @default.
• W2149269875 hasAuthorship W2149269875A5022669876 @default.
• W2149269875 hasAuthorship W2149269875A5027121786 @default.
• W2149269875 hasAuthorship W2149269875A5030175585 @default.
• W2149269875 hasAuthorship W2149269875A5038207133 @default.
• W2149269875 hasAuthorship W2149269875A5039533635 @default.
• W2149269875 hasAuthorship W2149269875A5042104765 @default.
• W2149269875 hasAuthorship W2149269875A5046826386 @default.
• W2149269875 hasAuthorship W2149269875A5053243830 @default.
• W2149269875 hasAuthorship W2149269875A5054902055 @default.
• W2149269875 hasAuthorship W2149269875A5058412848 @default.
• W2149269875 hasAuthorship W2149269875A5059646387 @default.
• W2149269875 hasAuthorship W2149269875A5064440517 @default.
• W2149269875 hasAuthorship W2149269875A5066511998 @default.
• W2149269875 hasAuthorship W2149269875A5077199917 @default.
• W2149269875 hasAuthorship W2149269875A5077773904 @default.
• W2149269875 hasAuthorship W2149269875A5087541787 @default.
• W2149269875 hasAuthorship W2149269875A5089279058 @default.
• W2149269875 hasBestOaLocation W21492698751 @default.
• W2149269875 hasConcept C10162356 @default.
• W2149269875 hasConcept C126322002 @default.
• W2149269875 hasConcept C141071460 @default.
• W2149269875 hasConcept C164705383 @default.
• W2149269875 hasConcept C190283241 @default.
• W2149269875 hasConcept C207865475 @default.
• W2149269875 hasConcept C2776055305 @default.
• W2149269875 hasConcept C2776820930 @default.
• W2149269875 hasConcept C2777798775 @default.
• W2149269875 hasConcept C2779537366 @default.
• W2149269875 hasConcept C2780231137 @default.

• next