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- W2149272307 abstract "<h3>Objective</h3> To determine whether preoperative and/or postoperative central endothelial cell density (ECD) and its rate of decline postoperatively are predictive of graft failure caused by endothelial decompensation following penetrating keratoplasty to treat a moderate-risk condition, principally, Fuchs dystrophy or pseudophakic corneal edema. <h3>Methods</h3> In a subset of Cornea Donor Study participants, a central reading center determined preoperative and postoperative ECD from available specular images for 17 grafts that failed because of endothelial decompensation and 483 grafts that did not fail. <h3>Results</h3> Preoperative ECD was not predictive of graft failure caused by endothelial decompensation (<i>P</i> = .91). However, the 6-month ECD was predictive of subsequent failure (<i>P</i> < .001). Among those that had not failed within the first 6 months, the 5-year cumulative incidence (±95% confidence interval) of failure was 13% (±12%) for the 33 participants with a 6-month ECD of less than 1700 cells/mm<sup>2</sup>vs 2% (±3%) for the 137 participants with a 6-month ECD of 2500 cells/mm<sup>2</sup>or higher. After 5 years' follow-up, 40 of 277 participants (14%) with a clear graft had an ECD below 500 cells/mm<sup>2</sup>. <h3>Conclusions</h3> Preoperative ECD is unrelated to graft failure from endothelial decompensation, whereas there is a strong correlation of ECD at 6 months with graft failure from endothelial decompensation. A graft can remain clear after 5 years even when the ECD is below 500 cells/mm<sup>2</sup>. <h3>Clinical Trial Registry</h3> clinicaltrials.gov Identifier:NCT00006411" @default.
- W2149272307 created "2016-06-24" @default.
- W2149272307 creator A5080203373 @default.
- W2149272307 date "2010-01-01" @default.
- W2149272307 modified "2023-10-16" @default.
- W2149272307 title "Endothelial Cell Density to Predict Endothelial Graft Failure After Penetrating Keratoplasty" @default.
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- W2149272307 doi "https://doi.org/10.1001/archophthalmol.2010.128.63" @default.
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